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Adhesion molecules and cytokine production.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 2):S70-4.AR

Abstract

The exchange of cross-talks between cells relies on soluble factors or direct cell-cell contact. Soluble factors increase the expression of cell surface molecules that activate adjacent cells by direct contact to produce cytokines. In the lung, dendritic cells are potent inducers of T-cell proliferation, and the interaction between the two leads to the production of high amounts of TNF alpha and TNF beta. Of the molecules involved in these biologic functions, LFA-3, CD11c, and the combination of beta 1 and beta 2 integrins are the most efficient. However, blocking TNF alpha or TNF beta production does not affect the alloreaction. The interaction between activated T cells and monocytes resulted in a large production of IL-1 beta. In this reaction, CD69, CD2, and the beta 2 integrins (CD11a, b, c, and CD18) and also other molecules such as a 25- to 35-kD glycoprotein play an important part. Finally, interaction between monocytes and fibroblasts leads to the production of large amounts of collagenase and PGE2 by fibroblasts. Cell-associated IL-1, particularly IL-1 alpha and membrane-bound TNF alpha, can also play a crucial role in the process of cell-cell interaction. This interaction may be controlled by inhibitors to IL-1 and TNF.

Authors+Show Affiliations

Department of Medicine, University Hospital, Geneva, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8256926

Citation

Dayer, J M., et al. "Adhesion Molecules and Cytokine Production." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 2, 1993, pp. S70-4.
Dayer JM, Isler P, Nicod LP. Adhesion molecules and cytokine production. Am Rev Respir Dis. 1993;148(6 Pt 2):S70-4.
Dayer, J. M., Isler, P., & Nicod, L. P. (1993). Adhesion molecules and cytokine production. The American Review of Respiratory Disease, 148(6 Pt 2), S70-4.
Dayer JM, Isler P, Nicod LP. Adhesion Molecules and Cytokine Production. Am Rev Respir Dis. 1993;148(6 Pt 2):S70-4. PubMed PMID: 8256926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adhesion molecules and cytokine production. AU - Dayer,J M, AU - Isler,P, AU - Nicod,L P, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - S70 EP - 4 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 2 N2 - The exchange of cross-talks between cells relies on soluble factors or direct cell-cell contact. Soluble factors increase the expression of cell surface molecules that activate adjacent cells by direct contact to produce cytokines. In the lung, dendritic cells are potent inducers of T-cell proliferation, and the interaction between the two leads to the production of high amounts of TNF alpha and TNF beta. Of the molecules involved in these biologic functions, LFA-3, CD11c, and the combination of beta 1 and beta 2 integrins are the most efficient. However, blocking TNF alpha or TNF beta production does not affect the alloreaction. The interaction between activated T cells and monocytes resulted in a large production of IL-1 beta. In this reaction, CD69, CD2, and the beta 2 integrins (CD11a, b, c, and CD18) and also other molecules such as a 25- to 35-kD glycoprotein play an important part. Finally, interaction between monocytes and fibroblasts leads to the production of large amounts of collagenase and PGE2 by fibroblasts. Cell-associated IL-1, particularly IL-1 alpha and membrane-bound TNF alpha, can also play a crucial role in the process of cell-cell interaction. This interaction may be controlled by inhibitors to IL-1 and TNF. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256926/Adhesion_molecules_and_cytokine_production. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_2.S70?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -