Tags

Type your tag names separated by a space and hit enter

Determination of some butyrophenones in body fluids by gas chromatography with surface ionization detection.
Nihon Hoigaku Zasshi. 1993 Oct; 47(5):367-71.NH

Abstract

Haloperidol, moperone, pipamperone and bromperidol were found measurable with high sensitivity by gas chromatography (GC) with surface ionization detection (SID). The calibration curves using moperone as internal standard were linear in the range of 0.4-4 pmol on column for haloperidol, pipamperone, and bromperidol. The detection limit of the drugs was about 0.1 pmol on column. For their actual determination with forensic samples, a detailed procedure for their extraction from human whole blood and urine was established with Sep-Pak C18 cartridges. The recovery of the 4 drugs, which had been added to whole blood and urine, was more than 90%. Haloperidol in whole blood and urine of a schizophrenic patient, who had been administered with this drug (3 mg/day p.o.), could be quantitated by the present GC-SID, and the levels were 7.18 and 43.2 pmol/ml, respectively.

Authors+Show Affiliations

Department of Legal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8258900

Citation

Seno, H, et al. "Determination of some Butyrophenones in Body Fluids By Gas Chromatography With Surface Ionization Detection." Nihon Hoigaku Zasshi = the Japanese Journal of Legal Medicine, vol. 47, no. 5, 1993, pp. 367-71.
Seno H, Kumazawa T, Ishii A, et al. Determination of some butyrophenones in body fluids by gas chromatography with surface ionization detection. Nihon Hoigaku Zasshi. 1993;47(5):367-71.
Seno, H., Kumazawa, T., Ishii, A., Sato, K., & Suzuki, O. (1993). Determination of some butyrophenones in body fluids by gas chromatography with surface ionization detection. Nihon Hoigaku Zasshi = the Japanese Journal of Legal Medicine, 47(5), 367-71.
Seno H, et al. Determination of some Butyrophenones in Body Fluids By Gas Chromatography With Surface Ionization Detection. Nihon Hoigaku Zasshi. 1993;47(5):367-71. PubMed PMID: 8258900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of some butyrophenones in body fluids by gas chromatography with surface ionization detection. AU - Seno,H, AU - Kumazawa,T, AU - Ishii,A, AU - Sato,K, AU - Suzuki,O, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 367 EP - 71 JF - Nihon hoigaku zasshi = The Japanese journal of legal medicine JO - Nihon Hoigaku Zasshi VL - 47 IS - 5 N2 - Haloperidol, moperone, pipamperone and bromperidol were found measurable with high sensitivity by gas chromatography (GC) with surface ionization detection (SID). The calibration curves using moperone as internal standard were linear in the range of 0.4-4 pmol on column for haloperidol, pipamperone, and bromperidol. The detection limit of the drugs was about 0.1 pmol on column. For their actual determination with forensic samples, a detailed procedure for their extraction from human whole blood and urine was established with Sep-Pak C18 cartridges. The recovery of the 4 drugs, which had been added to whole blood and urine, was more than 90%. Haloperidol in whole blood and urine of a schizophrenic patient, who had been administered with this drug (3 mg/day p.o.), could be quantitated by the present GC-SID, and the levels were 7.18 and 43.2 pmol/ml, respectively. SN - 0047-1887 UR - https://www.unboundmedicine.com/medline/citation/8258900/Determination_of_some_butyrophenones_in_body_fluids_by_gas_chromatography_with_surface_ionization_detection_ DB - PRIME DP - Unbound Medicine ER -