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[A case of gastric amyloidosis developing into Bence-Jones type multiple myeloma, treated effectively by cyclo-VAMP chemotherapy].
Gan To Kagaku Ryoho. 1993 Dec; 20(15):2399-403.GT

Abstract

A 65-year-old man was admitted because of bleeding from gastric ulcer. A massive deposition of AL lambda type amyloid proteins in the gastric lesion was found. There were a few Bence-Jones (BJ) proteins in the urine, but serum M proteins and bone lesions were not found. Bone marrow puncture showed no dysplastic change of plasma cells. Moreover, there were no amyloid proteins deposited anywhere in the digestive tract examined, except for the stomach, nor were they found in the bone marrow, prostata, liver or kidney. Gastric amyloidosis was diagnosed. Gastrectomy was performed because of uncontrollable bleeding. Sixteen months later, bone swelling occurred in the sternoclavicular joint and the 3rd rib. At that time, plasma cells with dysplasia and increasing levels of urine BJ protein were revealed. BJ type multiple myeloma was finally diagnosed. For remission induction, cyclo-VAMP chemotherapy was given in 3 courses. Decreased levels of urine BJ protein, diminished bone lesion, normalization of bone marrow and fewer amyloid deposits were seen, and partial response was obtained. The patient is well with no signs of recurrence evident 42 months after treatment. This is an interesting case of initial gastric amyloidosis that developed into BJ type multiple myeloma and was effectively treated with cyclo-VAMP chemotherapy.

Authors+Show Affiliations

Third Dept. of Internal Medicine, Asahikawa Medical College.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

8259860

Citation

Ayabe, T, et al. "[A Case of Gastric Amyloidosis Developing Into Bence-Jones Type Multiple Myeloma, Treated Effectively By cyclo-VAMP Chemotherapy]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 20, no. 15, 1993, pp. 2399-403.
Ayabe T, Maekawa I, Ashida T, et al. [A case of gastric amyloidosis developing into Bence-Jones type multiple myeloma, treated effectively by cyclo-VAMP chemotherapy]. Gan To Kagaku Ryoho. 1993;20(15):2399-403.
Ayabe, T., Maekawa, I., Ashida, T., Taruishi, M., Shibata, Y., & Namiki, M. (1993). [A case of gastric amyloidosis developing into Bence-Jones type multiple myeloma, treated effectively by cyclo-VAMP chemotherapy]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 20(15), 2399-403.
Ayabe T, et al. [A Case of Gastric Amyloidosis Developing Into Bence-Jones Type Multiple Myeloma, Treated Effectively By cyclo-VAMP Chemotherapy]. Gan To Kagaku Ryoho. 1993;20(15):2399-403. PubMed PMID: 8259860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of gastric amyloidosis developing into Bence-Jones type multiple myeloma, treated effectively by cyclo-VAMP chemotherapy]. AU - Ayabe,T, AU - Maekawa,I, AU - Ashida,T, AU - Taruishi,M, AU - Shibata,Y, AU - Namiki,M, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 2399 EP - 403 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 20 IS - 15 N2 - A 65-year-old man was admitted because of bleeding from gastric ulcer. A massive deposition of AL lambda type amyloid proteins in the gastric lesion was found. There were a few Bence-Jones (BJ) proteins in the urine, but serum M proteins and bone lesions were not found. Bone marrow puncture showed no dysplastic change of plasma cells. Moreover, there were no amyloid proteins deposited anywhere in the digestive tract examined, except for the stomach, nor were they found in the bone marrow, prostata, liver or kidney. Gastric amyloidosis was diagnosed. Gastrectomy was performed because of uncontrollable bleeding. Sixteen months later, bone swelling occurred in the sternoclavicular joint and the 3rd rib. At that time, plasma cells with dysplasia and increasing levels of urine BJ protein were revealed. BJ type multiple myeloma was finally diagnosed. For remission induction, cyclo-VAMP chemotherapy was given in 3 courses. Decreased levels of urine BJ protein, diminished bone lesion, normalization of bone marrow and fewer amyloid deposits were seen, and partial response was obtained. The patient is well with no signs of recurrence evident 42 months after treatment. This is an interesting case of initial gastric amyloidosis that developed into BJ type multiple myeloma and was effectively treated with cyclo-VAMP chemotherapy. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/8259860/[A_case_of_gastric_amyloidosis_developing_into_Bence_Jones_type_multiple_myeloma_treated_effectively_by_cyclo_VAMP_chemotherapy]_ L2 - http://www.diseaseinfosearch.org/result/4962 DB - PRIME DP - Unbound Medicine ER -