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Pharmacological and immunohistochemical evidence for serotonergic modulation of cholinergic nucleus basalis neurons.
Eur J Neurosci 1993; 5(5):541-7EJ

Abstract

Identified electrophysiologically by low threshold bursts and transient outward rectification, cholinergic nucleus basalis neurons were recorded and labelled intracellularly in guinea-pig basal forebrain slices. By means of a triple labelling immunofluorescent technique, serotonin-immunoreactive fibres were visualized in close proximity to the soma and dendrites of the biocytin-labelled, choline acetyl transferase (ChAT)-immunoreactive cells. By bath application, 5-hydroxytryptamine (5-HT) produced a direct hyperpolarization of the identified cells which was mimicked by 5-HT1A receptor agonists, suggesting that it may inhibit the tonic firing but also modulate the low threshold bursting of the cholinergic nucleus basalis neurons.

Authors+Show Affiliations

Département de Physiologie, Centre Médical Universitaire, Geneva, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8261128

Citation

Khateb, A, et al. "Pharmacological and Immunohistochemical Evidence for Serotonergic Modulation of Cholinergic Nucleus Basalis Neurons." The European Journal of Neuroscience, vol. 5, no. 5, 1993, pp. 541-7.
Khateb A, Fort P, Alonso A, et al. Pharmacological and immunohistochemical evidence for serotonergic modulation of cholinergic nucleus basalis neurons. Eur J Neurosci. 1993;5(5):541-7.
Khateb, A., Fort, P., Alonso, A., Jones, B. E., & Mühlethaler, M. (1993). Pharmacological and immunohistochemical evidence for serotonergic modulation of cholinergic nucleus basalis neurons. The European Journal of Neuroscience, 5(5), pp. 541-7.
Khateb A, et al. Pharmacological and Immunohistochemical Evidence for Serotonergic Modulation of Cholinergic Nucleus Basalis Neurons. Eur J Neurosci. 1993 May 1;5(5):541-7. PubMed PMID: 8261128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological and immunohistochemical evidence for serotonergic modulation of cholinergic nucleus basalis neurons. AU - Khateb,A, AU - Fort,P, AU - Alonso,A, AU - Jones,B E, AU - Mühlethaler,M, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 541 EP - 7 JF - The European journal of neuroscience JO - Eur. J. Neurosci. VL - 5 IS - 5 N2 - Identified electrophysiologically by low threshold bursts and transient outward rectification, cholinergic nucleus basalis neurons were recorded and labelled intracellularly in guinea-pig basal forebrain slices. By means of a triple labelling immunofluorescent technique, serotonin-immunoreactive fibres were visualized in close proximity to the soma and dendrites of the biocytin-labelled, choline acetyl transferase (ChAT)-immunoreactive cells. By bath application, 5-hydroxytryptamine (5-HT) produced a direct hyperpolarization of the identified cells which was mimicked by 5-HT1A receptor agonists, suggesting that it may inhibit the tonic firing but also modulate the low threshold bursting of the cholinergic nucleus basalis neurons. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/8261128/Pharmacological_and_immunohistochemical_evidence_for_serotonergic_modulation_of_cholinergic_nucleus_basalis_neurons_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=1993&volume=5&issue=5&spage=541 DB - PRIME DP - Unbound Medicine ER -