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Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine.
J Pharmacol Exp Ther. 1993 Dec; 267(3):1445-53.JP

Abstract

The effects of dopamine (DA) and 5-hydroxytryptamine (5-HT) autoreceptor agents on electrically induced [3H]DA and [3H]5-HT release from superfused slices of striatum, nucleus accumbens and ventral mesencephalon (VM) containing A9 and A10 neurons were investigated in rats made tolerant to the stimulatory effect of cocaine on locomotor behavior by a 14-day continuous infusion of cocaine (29 mg/kg/day) by s.c. implanted osmotic minipumps followed by a 7-day drug-free period. In VM, electrically induced [3H]DA was increased, the ability of pergolide to inhibit this release was abolished, but the ability of sulpiride to facilitate the release was potentiated, implicating a higher concentration of synaptic DA modifying the responsiveness of somatodendritic D2 autoreceptors to D2 agents. Both electrically induced [3H]5-HT release from VM and the stimulatory effect of in vitro cocaine on this release were enhanced whereas the effects of both 5-methoxytryptamine and methiothepin were attenuated, indicating that subsensitivity of 5-HT autoreceptors developed in DA cell body regions. In striatum and nucleus accumbens, no significant changes were observed in [3H]DA and [3H]5-HT release, except for a modest reduction in the effects of both pergolide and sulpiride on electrically induced [3H]DA release from striatum. These results emphasize the importance of pretreatment-induced changes in DA cell body regions, rather than terminal areas, under the present conditions. The observed increase in DA autoinhibitory tone and subsensitivity of 5-HT release-regulating autoreceptors in the VM may contribute to the locomotor tolerance upon cocaine challenge after continuous cocaine.

Authors+Show Affiliations

Department of Basic Sciences, University of Illinois College of Medicine at Peoria.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8263807

Citation

Chen, N H., and M E. Reith. "Dopamine and Serotonin Release-regulating Autoreceptor Sensitivity in A9/A10 Cell Body and Terminal Areas After Withdrawal of Rats From Continuous Infusion of Cocaine." The Journal of Pharmacology and Experimental Therapeutics, vol. 267, no. 3, 1993, pp. 1445-53.
Chen NH, Reith ME. Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. J Pharmacol Exp Ther. 1993;267(3):1445-53.
Chen, N. H., & Reith, M. E. (1993). Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. The Journal of Pharmacology and Experimental Therapeutics, 267(3), 1445-53.
Chen NH, Reith ME. Dopamine and Serotonin Release-regulating Autoreceptor Sensitivity in A9/A10 Cell Body and Terminal Areas After Withdrawal of Rats From Continuous Infusion of Cocaine. J Pharmacol Exp Ther. 1993;267(3):1445-53. PubMed PMID: 8263807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. AU - Chen,N H, AU - Reith,M E, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1445 EP - 53 JF - The Journal of pharmacology and experimental therapeutics JO - J. Pharmacol. Exp. Ther. VL - 267 IS - 3 N2 - The effects of dopamine (DA) and 5-hydroxytryptamine (5-HT) autoreceptor agents on electrically induced [3H]DA and [3H]5-HT release from superfused slices of striatum, nucleus accumbens and ventral mesencephalon (VM) containing A9 and A10 neurons were investigated in rats made tolerant to the stimulatory effect of cocaine on locomotor behavior by a 14-day continuous infusion of cocaine (29 mg/kg/day) by s.c. implanted osmotic minipumps followed by a 7-day drug-free period. In VM, electrically induced [3H]DA was increased, the ability of pergolide to inhibit this release was abolished, but the ability of sulpiride to facilitate the release was potentiated, implicating a higher concentration of synaptic DA modifying the responsiveness of somatodendritic D2 autoreceptors to D2 agents. Both electrically induced [3H]5-HT release from VM and the stimulatory effect of in vitro cocaine on this release were enhanced whereas the effects of both 5-methoxytryptamine and methiothepin were attenuated, indicating that subsensitivity of 5-HT autoreceptors developed in DA cell body regions. In striatum and nucleus accumbens, no significant changes were observed in [3H]DA and [3H]5-HT release, except for a modest reduction in the effects of both pergolide and sulpiride on electrically induced [3H]DA release from striatum. These results emphasize the importance of pretreatment-induced changes in DA cell body regions, rather than terminal areas, under the present conditions. The observed increase in DA autoinhibitory tone and subsensitivity of 5-HT release-regulating autoreceptors in the VM may contribute to the locomotor tolerance upon cocaine challenge after continuous cocaine. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/8263807/Dopamine_and_serotonin_release_regulating_autoreceptor_sensitivity_in_A9/A10_cell_body_and_terminal_areas_after_withdrawal_of_rats_from_continuous_infusion_of_cocaine_ L2 - http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=8263807 DB - PRIME DP - Unbound Medicine ER -