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Abnormal renal magnesium handling.
Miner Electrolyte Metab 1993; 19(4-5):232-40ME

Abstract

The normal fractional urinary excretion of filtered magnesium is about 5%. In magnesium deficiency in man, the kidneys can normally reduce the 24-hour urinary magnesium excretion to less than 1 mmol (24 mg) via unknown mechanisms, and initially without a fall in plasma magnesium concentration. Renal magnesium wasting may be defined as a urinary excretion greater than 1 mmol/day in the presence of hypomagnesemia (plasma magnesium < 0.7 mmol/l). Congenital renal magnesium wasting occurs in several syndromes including Bartter's syndrome in which it is associated with hypercalciuria, and the defect may be in the thick ascending limb of Henle's loop, and Gitelman's syndrome in which there is hypocalciuria, and the defect may be in the distal convoluted tubule. Other causes of renal magnesium wasting include diabetes mellitus, hypercalcemia and diuretics. Magnesium wasting may also result from various toxicities including those of cis-platinum, in which the biochemical features resemble Gitelman's syndrome, and those of aminoglycosides, pentamidine and cyclosporin. Calcitriol deficiency may also contribute to renal magnesium wasting in some circumstances. Mild hypermagnesemia may occur in familial hypocalciuric hypercalcemia and may reflect abnormal sensitivity of the loop of Henle to calcium and magnesium ions. By contrast, the hypermagnesemia that occurs in chronic renal failure results from the reduced glomerular filtration of magnesium.

Authors+Show Affiliations

Department of Medicine, University of British Columbia, Vancouver, Canada.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8264509

Citation

Sutton, R A., and S Domrongkitchaiporn. "Abnormal Renal Magnesium Handling." Mineral and Electrolyte Metabolism, vol. 19, no. 4-5, 1993, pp. 232-40.
Sutton RA, Domrongkitchaiporn S. Abnormal renal magnesium handling. Miner Electrolyte Metab. 1993;19(4-5):232-40.
Sutton, R. A., & Domrongkitchaiporn, S. (1993). Abnormal renal magnesium handling. Mineral and Electrolyte Metabolism, 19(4-5), pp. 232-40.
Sutton RA, Domrongkitchaiporn S. Abnormal Renal Magnesium Handling. Miner Electrolyte Metab. 1993;19(4-5):232-40. PubMed PMID: 8264509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal renal magnesium handling. AU - Sutton,R A, AU - Domrongkitchaiporn,S, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 232 EP - 40 JF - Mineral and electrolyte metabolism JO - Miner Electrolyte Metab VL - 19 IS - 4-5 N2 - The normal fractional urinary excretion of filtered magnesium is about 5%. In magnesium deficiency in man, the kidneys can normally reduce the 24-hour urinary magnesium excretion to less than 1 mmol (24 mg) via unknown mechanisms, and initially without a fall in plasma magnesium concentration. Renal magnesium wasting may be defined as a urinary excretion greater than 1 mmol/day in the presence of hypomagnesemia (plasma magnesium < 0.7 mmol/l). Congenital renal magnesium wasting occurs in several syndromes including Bartter's syndrome in which it is associated with hypercalciuria, and the defect may be in the thick ascending limb of Henle's loop, and Gitelman's syndrome in which there is hypocalciuria, and the defect may be in the distal convoluted tubule. Other causes of renal magnesium wasting include diabetes mellitus, hypercalcemia and diuretics. Magnesium wasting may also result from various toxicities including those of cis-platinum, in which the biochemical features resemble Gitelman's syndrome, and those of aminoglycosides, pentamidine and cyclosporin. Calcitriol deficiency may also contribute to renal magnesium wasting in some circumstances. Mild hypermagnesemia may occur in familial hypocalciuric hypercalcemia and may reflect abnormal sensitivity of the loop of Henle to calcium and magnesium ions. By contrast, the hypermagnesemia that occurs in chronic renal failure results from the reduced glomerular filtration of magnesium. SN - 0378-0392 UR - https://www.unboundmedicine.com/medline/citation/8264509/Abnormal_renal_magnesium_handling_ L2 - https://medlineplus.gov/kidneydiseases.html DB - PRIME DP - Unbound Medicine ER -