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Anti pneumococcal antibody activity in nasopharyngeal secretions in healthy adults and children.
Acta Otolaryngol. 1993 Sep; 113(5):673-8.AO

Abstract

The local antibody activity to Streptococcus pneumoniae serotype 6B was measured in nasopharyngeal secretions from 20 healthy adults and 43 children, 1-3 years of age, 14 of whom were healthy and 29 were at risk for developing recurrent episodes of acute otitis media (RAOM) according to the criteria described below. In children, anti pneumococcal IgA and IgG antibody activity was of the same magnitude in both groups. Adults showed significantly higher specific IgA activity. Antibody activity of the IgG isotype was also higher in adults, possibly reflecting the higher serum antibody levels. The children at risk of developing RAOM had significantly higher levels of secretory component (SC) in their nasopharyngeal secretions. Our data suggest that local immunity in the nasopharynx is not fully developed in young children, which might contribute to bacterial survival and colonization in the region.

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Authors+Show Affiliations

Lindberg K
Department of Oto-Rhino-Laryngology, Huddinge University Hospital, Sweden.
Freijd A
No affiliation info available
Rynnel-Dagöö B
No affiliation info available
Hammarström L
No affiliation info available

MeSH

Acute DiseaseAdultAge FactorsAntibodies, BacterialChild, PreschoolDisease SusceptibilityEnzyme-Linked Immunosorbent AssayExudates and TransudatesHumansImmunoglobulin AImmunoglobulin GInfantNasopharynxOtitis MediaRecurrenceSecretory ComponentStreptococcus pneumoniae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8266798

Citation

Lindberg, K, et al. "Anti Pneumococcal Antibody Activity in Nasopharyngeal Secretions in Healthy Adults and Children." Acta Oto-laryngologica, vol. 113, no. 5, 1993, pp. 673-8.
Lindberg K, Freijd A, Rynnel-Dagöö B, et al. Anti pneumococcal antibody activity in nasopharyngeal secretions in healthy adults and children. Acta Otolaryngol. 1993;113(5):673-8.
Lindberg, K., Freijd, A., Rynnel-Dagöö, B., & Hammarström, L. (1993). Anti pneumococcal antibody activity in nasopharyngeal secretions in healthy adults and children. Acta Oto-laryngologica, 113(5), 673-8.
Lindberg K, et al. Anti Pneumococcal Antibody Activity in Nasopharyngeal Secretions in Healthy Adults and Children. Acta Otolaryngol. 1993;113(5):673-8. PubMed PMID: 8266798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti pneumococcal antibody activity in nasopharyngeal secretions in healthy adults and children. AU - Lindberg,K, AU - Freijd,A, AU - Rynnel-Dagöö,B, AU - Hammarström,L, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 673 EP - 8 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 113 IS - 5 N2 - The local antibody activity to Streptococcus pneumoniae serotype 6B was measured in nasopharyngeal secretions from 20 healthy adults and 43 children, 1-3 years of age, 14 of whom were healthy and 29 were at risk for developing recurrent episodes of acute otitis media (RAOM) according to the criteria described below. In children, anti pneumococcal IgA and IgG antibody activity was of the same magnitude in both groups. Adults showed significantly higher specific IgA activity. Antibody activity of the IgG isotype was also higher in adults, possibly reflecting the higher serum antibody levels. The children at risk of developing RAOM had significantly higher levels of secretory component (SC) in their nasopharyngeal secretions. Our data suggest that local immunity in the nasopharynx is not fully developed in young children, which might contribute to bacterial survival and colonization in the region. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/8266798/Anti_pneumococcal_antibody_activity_in_nasopharyngeal_secretions_in_healthy_adults_and_children_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016489309135883 DB - PRIME DP - Unbound Medicine ER -