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A comparison of the joint effects of alcohol and smoking on the risk of cancer across sites in the upper aerodigestive tract.
Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec; 2(6):519-23.CE

Abstract

A unified analysis of the combined effects of alcohol and smoking in cancers of the upper aerodigestive tract was conducted using polychotomous logistic regression to determine if, at the same level of exposure, risk varies significantly across pathological sites. Data from a case-control study in northern Italy include males with tumors of the oral cavity/pharynx, larynx, and esophagus and males admitted to the hospital for acute illnesses not related to alcohol and smoking. The combined alcohol and smoking risks for oral cavity/pharynx cancer in these data were significantly greater than those for either laryngeal or esophageal cancer, but esophageal cancer and laryngeal cancer could not be distinguished based on risk. The differences may lie in the presence of unspecified factors in the oral cavity and pharynx, but not in the other upper aerodigestive tract sites, which potentiate the effects of alcohol and smoking in the oral cavity/pharynx.

Authors+Show Affiliations

Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8268767

Citation

Barón, A E., et al. "A Comparison of the Joint Effects of Alcohol and Smoking On the Risk of Cancer Across Sites in the Upper Aerodigestive Tract." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 2, no. 6, 1993, pp. 519-23.
Barón AE, Franceschi S, Barra S, et al. A comparison of the joint effects of alcohol and smoking on the risk of cancer across sites in the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev. 1993;2(6):519-23.
Barón, A. E., Franceschi, S., Barra, S., Talamini, R., & La Vecchia, C. (1993). A comparison of the joint effects of alcohol and smoking on the risk of cancer across sites in the upper aerodigestive tract. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 2(6), 519-23.
Barón AE, et al. A Comparison of the Joint Effects of Alcohol and Smoking On the Risk of Cancer Across Sites in the Upper Aerodigestive Tract. Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec;2(6):519-23. PubMed PMID: 8268767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the joint effects of alcohol and smoking on the risk of cancer across sites in the upper aerodigestive tract. AU - Barón,A E, AU - Franceschi,S, AU - Barra,S, AU - Talamini,R, AU - La Vecchia,C, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 519 EP - 23 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 2 IS - 6 N2 - A unified analysis of the combined effects of alcohol and smoking in cancers of the upper aerodigestive tract was conducted using polychotomous logistic regression to determine if, at the same level of exposure, risk varies significantly across pathological sites. Data from a case-control study in northern Italy include males with tumors of the oral cavity/pharynx, larynx, and esophagus and males admitted to the hospital for acute illnesses not related to alcohol and smoking. The combined alcohol and smoking risks for oral cavity/pharynx cancer in these data were significantly greater than those for either laryngeal or esophageal cancer, but esophageal cancer and laryngeal cancer could not be distinguished based on risk. The differences may lie in the presence of unspecified factors in the oral cavity and pharynx, but not in the other upper aerodigestive tract sites, which potentiate the effects of alcohol and smoking in the oral cavity/pharynx. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/8268767/A_comparison_of_the_joint_effects_of_alcohol_and_smoking_on_the_risk_of_cancer_across_sites_in_the_upper_aerodigestive_tract_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8268767 DB - PRIME DP - Unbound Medicine ER -