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Detection of amphetamine and methamphetamine in urine by gas chromatography/Fourier transform infrared (GC/FTIR) spectroscopy.
J Anal Toxicol. 1993 Oct; 17(6):359-64.JA

Abstract

New methods for identification of amphetamines have been employed using gas chromatography/Fourier transform infrared spectroscopy (GC/FTIR). These methods have provided identification of the drug and its metabolites, with detection at the low picogram levels or less than 10 ng/mL. Developments in cryogenic sample deposition for GC/FTIR spectroscopy have increased the sensitivity of GC/FTIR to levels that match or surpass that of gas chromatography/mass spectrometry (GC/MS). This advancement in technology has allowed the highly selective ability of infrared spectroscopy to be used for identification and quantitation in studies where the analytes are in low concentrations. The limits of detection (LOD), quantitation (LOQ), and linearity (LOL), and precision have been determined in this study, and these instrumental parameters have been compared with those of established techniques.

Authors+Show Affiliations

Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8271783

Citation

Kalasinsky, K S., et al. "Detection of Amphetamine and Methamphetamine in Urine By Gas chromatography/Fourier Transform Infrared (GC/FTIR) Spectroscopy." Journal of Analytical Toxicology, vol. 17, no. 6, 1993, pp. 359-64.
Kalasinsky KS, Levine B, Smith ML, et al. Detection of amphetamine and methamphetamine in urine by gas chromatography/Fourier transform infrared (GC/FTIR) spectroscopy. J Anal Toxicol. 1993;17(6):359-64.
Kalasinsky, K. S., Levine, B., Smith, M. L., Magluilo, J., & Schaefer, T. (1993). Detection of amphetamine and methamphetamine in urine by gas chromatography/Fourier transform infrared (GC/FTIR) spectroscopy. Journal of Analytical Toxicology, 17(6), 359-64.
Kalasinsky KS, et al. Detection of Amphetamine and Methamphetamine in Urine By Gas chromatography/Fourier Transform Infrared (GC/FTIR) Spectroscopy. J Anal Toxicol. 1993;17(6):359-64. PubMed PMID: 8271783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of amphetamine and methamphetamine in urine by gas chromatography/Fourier transform infrared (GC/FTIR) spectroscopy. AU - Kalasinsky,K S, AU - Levine,B, AU - Smith,M L, AU - Magluilo,J,Jr AU - Schaefer,T, PY - 1993/10/1/pubmed PY - 2001/3/28/medline PY - 1993/10/1/entrez SP - 359 EP - 64 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 17 IS - 6 N2 - New methods for identification of amphetamines have been employed using gas chromatography/Fourier transform infrared spectroscopy (GC/FTIR). These methods have provided identification of the drug and its metabolites, with detection at the low picogram levels or less than 10 ng/mL. Developments in cryogenic sample deposition for GC/FTIR spectroscopy have increased the sensitivity of GC/FTIR to levels that match or surpass that of gas chromatography/mass spectrometry (GC/MS). This advancement in technology has allowed the highly selective ability of infrared spectroscopy to be used for identification and quantitation in studies where the analytes are in low concentrations. The limits of detection (LOD), quantitation (LOQ), and linearity (LOL), and precision have been determined in this study, and these instrumental parameters have been compared with those of established techniques. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/8271783/Detection_of_amphetamine_and_methamphetamine_in_urine_by_gas_chromatography/Fourier_transform_infrared__GC/FTIR__spectroscopy_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/17.6.359 DB - PRIME DP - Unbound Medicine ER -