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A randomized controlled trial of solcoseryl and duoderm in chronic sickle-cell ulcers.
West Indian Med J 1993; 42(3):121-3WI

Abstract

A randomized controlled trial of Solcoseryl, DuoDerm and conventional conservative therapy with Eusol has been performed in 32 patients with homozygous sickle-cell (SS) disease. After 12 weeks' baseline observation, patients were randomized to one of three therapies and monitored for a further 12 weeks. Of 44 ulcerated legs, 20 received control treatment, 12 Solcoseryl and 12 DuoDerm. DuoDerm was generally unacceptable, and two-thirds of the patients defaulted from this treatment. Solcoseryl increased ulcer healing compared to the controls but the difference was not significant. Solcoseryl was well tolerated and may have a role in the treatment of chronic leg ulcers of sickle-cell disease.

Authors+Show Affiliations

Department of Medicine, U.W.I., Jamaica.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8273321

Citation

La Grenade, L, et al. "A Randomized Controlled Trial of Solcoseryl and Duoderm in Chronic Sickle-cell Ulcers." The West Indian Medical Journal, vol. 42, no. 3, 1993, pp. 121-3.
La Grenade L, Thomas PW, Serjeant GR. A randomized controlled trial of solcoseryl and duoderm in chronic sickle-cell ulcers. West Indian Med J. 1993;42(3):121-3.
La Grenade, L., Thomas, P. W., & Serjeant, G. R. (1993). A randomized controlled trial of solcoseryl and duoderm in chronic sickle-cell ulcers. The West Indian Medical Journal, 42(3), pp. 121-3.
La Grenade L, Thomas PW, Serjeant GR. A Randomized Controlled Trial of Solcoseryl and Duoderm in Chronic Sickle-cell Ulcers. West Indian Med J. 1993;42(3):121-3. PubMed PMID: 8273321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized controlled trial of solcoseryl and duoderm in chronic sickle-cell ulcers. AU - La Grenade,L, AU - Thomas,P W, AU - Serjeant,G R, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 121 EP - 3 JF - The West Indian medical journal JO - West Indian Med J VL - 42 IS - 3 N2 - A randomized controlled trial of Solcoseryl, DuoDerm and conventional conservative therapy with Eusol has been performed in 32 patients with homozygous sickle-cell (SS) disease. After 12 weeks' baseline observation, patients were randomized to one of three therapies and monitored for a further 12 weeks. Of 44 ulcerated legs, 20 received control treatment, 12 Solcoseryl and 12 DuoDerm. DuoDerm was generally unacceptable, and two-thirds of the patients defaulted from this treatment. Solcoseryl increased ulcer healing compared to the controls but the difference was not significant. Solcoseryl was well tolerated and may have a role in the treatment of chronic leg ulcers of sickle-cell disease. SN - 0043-3144 UR - https://www.unboundmedicine.com/medline/citation/8273321/A_randomized_controlled_trial_of_solcoseryl_and_duoderm_in_chronic_sickle_cell_ulcers_ L2 - https://medlineplus.gov/leginjuriesanddisorders.html DB - PRIME DP - Unbound Medicine ER -