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The renal proximal tubule renin-angiotensin system.
Semin Nephrol. 1993 Nov; 13(6):552-7.SN

Abstract

In conclusion, a complete RAS is present in the mammalian proximal tubule that is potentially autocrine and paracrine in nature. Maneuvers that stimulate renin in JG cells and renal vasculature appear to also stimulate renin in the proximal tubule. The subcellular localization of the different components and the regulation of this epithelial RAS still remain to be defined. This RAS may be important in regulation of proximal tubule NaCl and NaHCO3 transport. Finally, one can speculate that activation of this RAS may play a pathogenetic role in some patients with essential hypertension and in the hypertension and cyst growth seen in autosomal dominant polycystic kidney disease.

Authors+Show Affiliations

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8856.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8278688

Citation

Moe, O W., et al. "The Renal Proximal Tubule Renin-angiotensin System." Seminars in Nephrology, vol. 13, no. 6, 1993, pp. 552-7.
Moe OW, Alpern RJ, Henrich WL. The renal proximal tubule renin-angiotensin system. Semin Nephrol. 1993;13(6):552-7.
Moe, O. W., Alpern, R. J., & Henrich, W. L. (1993). The renal proximal tubule renin-angiotensin system. Seminars in Nephrology, 13(6), 552-7.
Moe OW, Alpern RJ, Henrich WL. The Renal Proximal Tubule Renin-angiotensin System. Semin Nephrol. 1993;13(6):552-7. PubMed PMID: 8278688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The renal proximal tubule renin-angiotensin system. AU - Moe,O W, AU - Alpern,R J, AU - Henrich,W L, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 552 EP - 7 JF - Seminars in nephrology JO - Semin. Nephrol. VL - 13 IS - 6 N2 - In conclusion, a complete RAS is present in the mammalian proximal tubule that is potentially autocrine and paracrine in nature. Maneuvers that stimulate renin in JG cells and renal vasculature appear to also stimulate renin in the proximal tubule. The subcellular localization of the different components and the regulation of this epithelial RAS still remain to be defined. This RAS may be important in regulation of proximal tubule NaCl and NaHCO3 transport. Finally, one can speculate that activation of this RAS may play a pathogenetic role in some patients with essential hypertension and in the hypertension and cyst growth seen in autosomal dominant polycystic kidney disease. SN - 0270-9295 UR - https://www.unboundmedicine.com/medline/citation/8278688/The_renal_proximal_tubule_renin_angiotensin_system_ DB - PRIME DP - Unbound Medicine ER -