Tags

Type your tag names separated by a space and hit enter

Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines.
Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1443-9.BB

Abstract

Platelet-activating factor is a potent phospholipid mediator which produces a wide range of biological responses by binding to a specific, high-affinity receptor on the target cell surface. Platelet-activating factor has been shown to have a very important pro-inflammatory role while the cytokine transforming growth factor-beta, also known for its diverse and potent effects, can act as both a pro- and anti-inflammatory agent. To ascertain whether transforming growth factor-beta could modulate the expression of the human platelet-activating factor receptor, different cell types were stimulated with this cytokine and the effect determined by Northern blot analysis and Ca2+ influx studies. The results demonstrate that transforming growth factor-beta induces the expression of the platelet-activating factor receptor in monocytic and B cell lines and indicate that transforming growth factor-beta could play a role in the modulation of the inflammatory response by up-regulating the expression of the platelet-activating factor receptor.

Authors+Show Affiliations

Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8280163

Citation

Parent, J L., and J Stankova. "Transforming Growth Factor-beta Up-regulates the Gene Expression of the Human Platelet-activating Factor Receptor in Monocytic and B Cell Lines." Biochemical and Biophysical Research Communications, vol. 197, no. 3, 1993, pp. 1443-9.
Parent JL, Stankova J. Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. Biochem Biophys Res Commun. 1993;197(3):1443-9.
Parent, J. L., & Stankova, J. (1993). Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. Biochemical and Biophysical Research Communications, 197(3), 1443-9.
Parent JL, Stankova J. Transforming Growth Factor-beta Up-regulates the Gene Expression of the Human Platelet-activating Factor Receptor in Monocytic and B Cell Lines. Biochem Biophys Res Commun. 1993 Dec 30;197(3):1443-9. PubMed PMID: 8280163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. AU - Parent,J L, AU - Stankova,J, PY - 1993/12/30/pubmed PY - 1993/12/30/medline PY - 1993/12/30/entrez SP - 1443 EP - 9 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 197 IS - 3 N2 - Platelet-activating factor is a potent phospholipid mediator which produces a wide range of biological responses by binding to a specific, high-affinity receptor on the target cell surface. Platelet-activating factor has been shown to have a very important pro-inflammatory role while the cytokine transforming growth factor-beta, also known for its diverse and potent effects, can act as both a pro- and anti-inflammatory agent. To ascertain whether transforming growth factor-beta could modulate the expression of the human platelet-activating factor receptor, different cell types were stimulated with this cytokine and the effect determined by Northern blot analysis and Ca2+ influx studies. The results demonstrate that transforming growth factor-beta induces the expression of the platelet-activating factor receptor in monocytic and B cell lines and indicate that transforming growth factor-beta could play a role in the modulation of the inflammatory response by up-regulating the expression of the platelet-activating factor receptor. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/8280163/Transforming_growth_factor_beta_up_regulates_the_gene_expression_of_the_human_platelet_activating_factor_receptor_in_monocytic_and_B_cell_lines_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(83)72639-2 DB - PRIME DP - Unbound Medicine ER -