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In vivo EPR measurement of radical reaction in whole mice--influence of inspired oxygen and ischemia-reperfusion injury on nitroxide reduction.
Free Radic Res Commun 1993; 19 Suppl 1:S219-25FR

Abstract

In vivo EPR measurements were carried out with whole mice to evaluate the influence of inspired oxygen and ischemia-reperfusion injury on spin-clearance of the nitroxide radicals which were administered intravenously or intramuscularly. Nitroxide radicals in head, abdomen, or muscle domains were composed of sharp triplet lines. The peak heights decreased gradually with time. The reduction of nitroxide radicals depended both on the inspired oxygen concentration and on the domains. Femoral ischemia-reperfusion injury also affected spin-clearance of the nitroxide radical in the thigh. The results were discussed with regard to the generation of active oxygen species.

Authors+Show Affiliations

Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8282227

Citation

Utsumi, H, et al. "In Vivo EPR Measurement of Radical Reaction in Whole Mice--influence of Inspired Oxygen and Ischemia-reperfusion Injury On Nitroxide Reduction." Free Radical Research Communications, vol. 19 Suppl 1, 1993, pp. S219-25.
Utsumi H, Takeshita K, Miura Y, et al. In vivo EPR measurement of radical reaction in whole mice--influence of inspired oxygen and ischemia-reperfusion injury on nitroxide reduction. Free Radic Res Commun. 1993;19 Suppl 1:S219-25.
Utsumi, H., Takeshita, K., Miura, Y., Masuda, S., & Hamada, A. (1993). In vivo EPR measurement of radical reaction in whole mice--influence of inspired oxygen and ischemia-reperfusion injury on nitroxide reduction. Free Radical Research Communications, 19 Suppl 1, pp. S219-25.
Utsumi H, et al. In Vivo EPR Measurement of Radical Reaction in Whole Mice--influence of Inspired Oxygen and Ischemia-reperfusion Injury On Nitroxide Reduction. Free Radic Res Commun. 1993;19 Suppl 1:S219-25. PubMed PMID: 8282227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo EPR measurement of radical reaction in whole mice--influence of inspired oxygen and ischemia-reperfusion injury on nitroxide reduction. AU - Utsumi,H, AU - Takeshita,K, AU - Miura,Y, AU - Masuda,S, AU - Hamada,A, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - S219 EP - 25 JF - Free radical research communications JO - Free Radic. Res. Commun. VL - 19 Suppl 1 N2 - In vivo EPR measurements were carried out with whole mice to evaluate the influence of inspired oxygen and ischemia-reperfusion injury on spin-clearance of the nitroxide radicals which were administered intravenously or intramuscularly. Nitroxide radicals in head, abdomen, or muscle domains were composed of sharp triplet lines. The peak heights decreased gradually with time. The reduction of nitroxide radicals depended both on the inspired oxygen concentration and on the domains. Femoral ischemia-reperfusion injury also affected spin-clearance of the nitroxide radical in the thigh. The results were discussed with regard to the generation of active oxygen species. SN - 8755-0199 UR - https://www.unboundmedicine.com/medline/citation/8282227/In_vivo_EPR_measurement_of_radical_reaction_in_whole_mice__influence_of_inspired_oxygen_and_ischemia_reperfusion_injury_on_nitroxide_reduction_ DB - PRIME DP - Unbound Medicine ER -