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Naltrexone in autistic children: behavioral symptoms and attentional learning.
J Am Acad Child Adolesc Psychiatry. 1993 Nov; 32(6):1283-91.JA

Abstract

OBJECTIVE

To assess critically the short-term efficacy and safety of naltrexone in autistic children and its effects on discrimination learning in the laboratory.

METHOD

A parallel group design was employed. After a 2-week placebo baseline period, children were randomly assigned either to naltrexone or to placebo for a period of 3 weeks followed by a one-week posttreatment placebo period. Multiple raters and rating scales were employed in a variety of conditions. Forty-one children, all inpatients, ages 2.9 to 7.8 years, completed the study. Naltrexone reduced hyperactivity and had no effect on discrimination learning in the laboratory. There was a suggestion that it had a beneficial effect on decreasing self-injurious behavior. Untoward effects were mild and transient.

CONCLUSION

In the present study, naltrexone significantly reduced only hyperactivity, and no serious untoward effects were observed. The effectiveness of naltrexone in the treatment of autism and self-injurious behavior requires additional assessment in a sample of children with moderate to severe self-injurious behavior.

Authors+Show Affiliations

Department of Psychiatry, New York University Medical Center, NY 10016.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8282676

Citation

Campbell, M, et al. "Naltrexone in Autistic Children: Behavioral Symptoms and Attentional Learning." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 32, no. 6, 1993, pp. 1283-91.
Campbell M, Anderson LT, Small AM, et al. Naltrexone in autistic children: behavioral symptoms and attentional learning. J Am Acad Child Adolesc Psychiatry. 1993;32(6):1283-91.
Campbell, M., Anderson, L. T., Small, A. M., Adams, P., Gonzalez, N. M., & Ernst, M. (1993). Naltrexone in autistic children: behavioral symptoms and attentional learning. Journal of the American Academy of Child and Adolescent Psychiatry, 32(6), 1283-91.
Campbell M, et al. Naltrexone in Autistic Children: Behavioral Symptoms and Attentional Learning. J Am Acad Child Adolesc Psychiatry. 1993;32(6):1283-91. PubMed PMID: 8282676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Naltrexone in autistic children: behavioral symptoms and attentional learning. AU - Campbell,M, AU - Anderson,L T, AU - Small,A M, AU - Adams,P, AU - Gonzalez,N M, AU - Ernst,M, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 1283 EP - 91 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 32 IS - 6 N2 - OBJECTIVE: To assess critically the short-term efficacy and safety of naltrexone in autistic children and its effects on discrimination learning in the laboratory. METHOD: A parallel group design was employed. After a 2-week placebo baseline period, children were randomly assigned either to naltrexone or to placebo for a period of 3 weeks followed by a one-week posttreatment placebo period. Multiple raters and rating scales were employed in a variety of conditions. Forty-one children, all inpatients, ages 2.9 to 7.8 years, completed the study. Naltrexone reduced hyperactivity and had no effect on discrimination learning in the laboratory. There was a suggestion that it had a beneficial effect on decreasing self-injurious behavior. Untoward effects were mild and transient. CONCLUSION: In the present study, naltrexone significantly reduced only hyperactivity, and no serious untoward effects were observed. The effectiveness of naltrexone in the treatment of autism and self-injurious behavior requires additional assessment in a sample of children with moderate to severe self-injurious behavior. SN - 0890-8567 UR - https://www.unboundmedicine.com/medline/citation/8282676/Naltrexone_in_autistic_children:_behavioral_symptoms_and_attentional_learning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(09)64530-5 DB - PRIME DP - Unbound Medicine ER -