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Does antral distension inhibit gastric acid secretion or stimulate bicarbonate secretion in 'healthy' subjects?
Scand J Gastroenterol. 1993 Nov; 28(11):999-1004.SJ

Abstract

The effects of a 150-ml antral balloon distension on pentagastrin-stimulated gastric acid secretion and bicarbonate secretion were studied in nine healthy subjects and eight duodenal ulcer (DU) patients. The gastric secretions were simultaneously measured, using a luminal perfusion and pH/PCO2 measurements. Two of the healthy subjects and six of the DU patients were positive for Helicobacter pylori. When H. pylori-positive and -negative subjects were compared, basal gastric acid and bicarbonate outputs did not differ significantly. In H. pylori-infected subjects the bicarbonate transport increased by about 70% on pentagastrin stimulation. In the H. pylori-negative group pentagastrin had no effect on the bicarbonate secretion. Antral distension elicited a 30-35% inhibition of pentagastrin-stimulated gastric acid secretion in the group of H. pylori-negative subjects, whereas the acid secretory level remained essentially unchanged in the positive group. Bicarbonate secretion decreased transiently by the distension in the negative subjects, whereas a slight increase was observed in the infected group. We conclude that antral distension inhibits pentagastrin-stimulated gastric acid output in healthy H. pylori-negative subjects. Our results strongly suggest that the underlying mechanism is a direct inhibition of gastric parietal cell function and not an increased gastric bicarbonate secretion. Furthermore, the results indicate that this defective distension-induced acid inhibition may be correlated to H. pylori infection rather than to duodenal ulcer disease.

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Authors+Show Affiliations

Hamlet A
Dept. of Physiology, University of Gothenburg, Sweden.
Dalenbäck J
No affiliation info available
Olbe L
No affiliation info available
Fändriks L
No affiliation info available

MeSH

AdultAgedBicarbonatesCatheterizationDuodenal UlcerFemaleGastric AcidHelicobacter InfectionsHelicobacter pyloriHumansIntubation, GastrointestinalMaleMiddle AgedParietal Cells, GastricPentagastrinPyloric Antrum

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8284638

Citation

Hamlet, A, et al. "Does Antral Distension Inhibit Gastric Acid Secretion or Stimulate Bicarbonate Secretion in 'healthy' Subjects?" Scandinavian Journal of Gastroenterology, vol. 28, no. 11, 1993, pp. 999-1004.
Hamlet A, Dalenbäck J, Olbe L, et al. Does antral distension inhibit gastric acid secretion or stimulate bicarbonate secretion in 'healthy' subjects? Scand J Gastroenterol. 1993;28(11):999-1004.
Hamlet, A., Dalenbäck, J., Olbe, L., & Fändriks, L. (1993). Does antral distension inhibit gastric acid secretion or stimulate bicarbonate secretion in 'healthy' subjects? Scandinavian Journal of Gastroenterology, 28(11), 999-1004.
Hamlet A, et al. Does Antral Distension Inhibit Gastric Acid Secretion or Stimulate Bicarbonate Secretion in 'healthy' Subjects. Scand J Gastroenterol. 1993;28(11):999-1004. PubMed PMID: 8284638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does antral distension inhibit gastric acid secretion or stimulate bicarbonate secretion in 'healthy' subjects? AU - Hamlet,A, AU - Dalenbäck,J, AU - Olbe,L, AU - Fändriks,L, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 999 EP - 1004 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 28 IS - 11 N2 - The effects of a 150-ml antral balloon distension on pentagastrin-stimulated gastric acid secretion and bicarbonate secretion were studied in nine healthy subjects and eight duodenal ulcer (DU) patients. The gastric secretions were simultaneously measured, using a luminal perfusion and pH/PCO2 measurements. Two of the healthy subjects and six of the DU patients were positive for Helicobacter pylori. When H. pylori-positive and -negative subjects were compared, basal gastric acid and bicarbonate outputs did not differ significantly. In H. pylori-infected subjects the bicarbonate transport increased by about 70% on pentagastrin stimulation. In the H. pylori-negative group pentagastrin had no effect on the bicarbonate secretion. Antral distension elicited a 30-35% inhibition of pentagastrin-stimulated gastric acid secretion in the group of H. pylori-negative subjects, whereas the acid secretory level remained essentially unchanged in the positive group. Bicarbonate secretion decreased transiently by the distension in the negative subjects, whereas a slight increase was observed in the infected group. We conclude that antral distension inhibits pentagastrin-stimulated gastric acid output in healthy H. pylori-negative subjects. Our results strongly suggest that the underlying mechanism is a direct inhibition of gastric parietal cell function and not an increased gastric bicarbonate secretion. Furthermore, the results indicate that this defective distension-induced acid inhibition may be correlated to H. pylori infection rather than to duodenal ulcer disease. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/8284638/Does_antral_distension_inhibit_gastric_acid_secretion_or_stimulate_bicarbonate_secretion_in_'healthy'_subjects L2 - https://www.tandfonline.com/doi/full/10.3109/00365529309098299 DB - PRIME DP - Unbound Medicine ER -