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1% amino acid peritoneal dialysate: single-cycle study in diabetic patients with end-stage renal disease.
Am J Kidney Dis. 1994 Jan; 23(1):86-90.AJ

Abstract

Uremia is associated with multiple abnormalities of carbohydrate and protein metabolism, which are partially corrected by continuous ambulatory peritoneal dialysis with dextrose-based solutions. The hormonal and metabolic effects of amino acid (AA)-based peritoneal dialysis have been studied in nondiabetic uremic patients. Such solutions may be particularly suitable for diabetic patients with end-stage renal disease provided the safety and efficacy of such solutions can be established. We have studied and compared the metabolic and hormonal responses to a single-cycle exchange of dextrose versus a 1% AA-based continuous ambulatory peritoneal dialysis solution in six diabetic patients with end-stage renal disease. In the fasting state and under similar free insulin concentrations, use of the AA solution led to a higher mean glucose concentration (109 +/- 16 mg/dL with dextrose solution v 128 +/- 25 mg/dL with AA solution, P < 0.05). Levels of alanine, lactate, pyruvate, glycerol, non-esterified fatty acids, and triglycerides were similar with the use of either solution. Use of the AA-based solution led to increases in the mean values of the branched chain AAs for the period of the study (valine 131 +/- 10 mumol/L with dextrose solution v 331 +/- 40 mumol/L with AA solution, P < 0.01; leucine 72 +/- 7 mumol/L with dextrose solution v 129 +/- 11 mumol/L with AA solution, P < 0.01; isoleucine 48 +/- 5 mumol/L with dextrose solution v 103 +/- 11 mumol/L with AA solution, P < 0.01).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Internal Medicine, University of Missouri Health Sciences Center, Columbia 65212.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8285202

Citation

Arfeen, S, et al. "1% Amino Acid Peritoneal Dialysate: Single-cycle Study in Diabetic Patients With End-stage Renal Disease." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 23, no. 1, 1994, pp. 86-90.
Arfeen S, Goodship TH, Kirkwood A, et al. 1% amino acid peritoneal dialysate: single-cycle study in diabetic patients with end-stage renal disease. Am J Kidney Dis. 1994;23(1):86-90.
Arfeen, S., Goodship, T. H., Kirkwood, A., Channon, S., & Ward, M. K. (1994). 1% amino acid peritoneal dialysate: single-cycle study in diabetic patients with end-stage renal disease. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 23(1), 86-90.
Arfeen S, et al. 1% Amino Acid Peritoneal Dialysate: Single-cycle Study in Diabetic Patients With End-stage Renal Disease. Am J Kidney Dis. 1994;23(1):86-90. PubMed PMID: 8285202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 1% amino acid peritoneal dialysate: single-cycle study in diabetic patients with end-stage renal disease. AU - Arfeen,S, AU - Goodship,T H, AU - Kirkwood,A, AU - Channon,S, AU - Ward,M K, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 86 EP - 90 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 23 IS - 1 N2 - Uremia is associated with multiple abnormalities of carbohydrate and protein metabolism, which are partially corrected by continuous ambulatory peritoneal dialysis with dextrose-based solutions. The hormonal and metabolic effects of amino acid (AA)-based peritoneal dialysis have been studied in nondiabetic uremic patients. Such solutions may be particularly suitable for diabetic patients with end-stage renal disease provided the safety and efficacy of such solutions can be established. We have studied and compared the metabolic and hormonal responses to a single-cycle exchange of dextrose versus a 1% AA-based continuous ambulatory peritoneal dialysis solution in six diabetic patients with end-stage renal disease. In the fasting state and under similar free insulin concentrations, use of the AA solution led to a higher mean glucose concentration (109 +/- 16 mg/dL with dextrose solution v 128 +/- 25 mg/dL with AA solution, P < 0.05). Levels of alanine, lactate, pyruvate, glycerol, non-esterified fatty acids, and triglycerides were similar with the use of either solution. Use of the AA-based solution led to increases in the mean values of the branched chain AAs for the period of the study (valine 131 +/- 10 mumol/L with dextrose solution v 331 +/- 40 mumol/L with AA solution, P < 0.01; leucine 72 +/- 7 mumol/L with dextrose solution v 129 +/- 11 mumol/L with AA solution, P < 0.01; isoleucine 48 +/- 5 mumol/L with dextrose solution v 103 +/- 11 mumol/L with AA solution, P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0272-6386 UR - https://www.unboundmedicine.com/medline/citation/8285202/1_amino_acid_peritoneal_dialysate:_single_cycle_study_in_diabetic_patients_with_end_stage_renal_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272638694000168 DB - PRIME DP - Unbound Medicine ER -