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Alzheimer's disease and Lewy body disease: a comparative clinicopathological study.
Ann Neurol. 1994 Jan; 35(1):81-8.AN

Abstract

The exact nature of the relationship between Lewy body disease and Alzheimer's disease (AD) is unknown. To investigate this, we compared cases of pure Lewy body disease, mixed Lewy body disease with AD, and pure AD to see what pathological features were shared and how they differed. We counted neurons, Lewy bodies, diffuse and neuritic senile plaques, neurofibrillary tangles, and neuropil threads in the frontal and medial temporal cortex and hippocampus from 5 autopsied cases of Lewy body disease (without AD histopathology), 7 with combined Lewy body disease and AD, 6 with AD, and 5 age-matched normal control subjects. Average neuronal counts in the cases with Lewy body disease were indistinguishable from those of control subjects, but higher than those for AD and combined Lewy body disease and AD. Diffuse plaque densities were similar in all disease forms. Neuritic senile plaques, neurofibrillary tangles, and neuropil threads were numerous in AD and combined Lewy body disease and AD, but sparse or absent in Lewy body disease and controls. Pure Lewy body disease and AD appear to be distinct clinicopathological entities except for the common feature of diffuse plaques in both disorders.

Authors+Show Affiliations

Department of Neurology, University of Massachusetts Medical Center, Worcester 01655.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8285597

Citation

Lippa, C F., et al. "Alzheimer's Disease and Lewy Body Disease: a Comparative Clinicopathological Study." Annals of Neurology, vol. 35, no. 1, 1994, pp. 81-8.
Lippa CF, Smith TW, Swearer JM. Alzheimer's disease and Lewy body disease: a comparative clinicopathological study. Ann Neurol. 1994;35(1):81-8.
Lippa, C. F., Smith, T. W., & Swearer, J. M. (1994). Alzheimer's disease and Lewy body disease: a comparative clinicopathological study. Annals of Neurology, 35(1), 81-8.
Lippa CF, Smith TW, Swearer JM. Alzheimer's Disease and Lewy Body Disease: a Comparative Clinicopathological Study. Ann Neurol. 1994;35(1):81-8. PubMed PMID: 8285597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alzheimer's disease and Lewy body disease: a comparative clinicopathological study. AU - Lippa,C F, AU - Smith,T W, AU - Swearer,J M, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 81 EP - 8 JF - Annals of neurology JO - Ann Neurol VL - 35 IS - 1 N2 - The exact nature of the relationship between Lewy body disease and Alzheimer's disease (AD) is unknown. To investigate this, we compared cases of pure Lewy body disease, mixed Lewy body disease with AD, and pure AD to see what pathological features were shared and how they differed. We counted neurons, Lewy bodies, diffuse and neuritic senile plaques, neurofibrillary tangles, and neuropil threads in the frontal and medial temporal cortex and hippocampus from 5 autopsied cases of Lewy body disease (without AD histopathology), 7 with combined Lewy body disease and AD, 6 with AD, and 5 age-matched normal control subjects. Average neuronal counts in the cases with Lewy body disease were indistinguishable from those of control subjects, but higher than those for AD and combined Lewy body disease and AD. Diffuse plaque densities were similar in all disease forms. Neuritic senile plaques, neurofibrillary tangles, and neuropil threads were numerous in AD and combined Lewy body disease and AD, but sparse or absent in Lewy body disease and controls. Pure Lewy body disease and AD appear to be distinct clinicopathological entities except for the common feature of diffuse plaques in both disorders. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8285597/Alzheimer's_disease_and_Lewy_body_disease:_a_comparative_clinicopathological_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1994&volume=35&issue=1&spage=81 DB - PRIME DP - Unbound Medicine ER -