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Cefpodoxime proxetil: a new, broad-spectrum, oral cephalosporin.
Ann Pharmacother. 1993 Nov; 27(11):1369-77.AP

Abstract

OBJECTIVE

To discuss the chemistry, pharmacokinetics, spectrum of activity, clinical trials, adverse effects, drug interactions, and dosage guidelines of cefpodoxime proxetil.

DATA SOURCES

Literature was identified through a MEDLINE search from 1988 to the present and from review of bibliographies in that literature.

STUDY SELECTION

Data were limited to comparative trials published in the English literature. Although many studies were conducted in Japan, the results often were available only in Japanese or partly in English. As these studies could not be completely evaluated, they are not included in this review.

DATA SYNTHESIS

Cefpodoxime exhibits good activity against many gram-positive and gram-negative organisms. In clinical trials, cefpodoxime was similar in both clinical and bacteriologic efficacy to amoxicillin, cefaclor, amoxicillin/clavulanate, and penicillin in the treatment of respiratory and urinary tract infections. It also appeared effective in the treatment of skin and soft tissue infections, although no comparative trials have been performed. Cefpodoxime is well tolerated by children and is effective in the treatment of otitis media and pharyngitis. It has a similar adverse effect profile to that of other penicillins and cephalosporins, with gastrointestinal effects being most common.

CONCLUSIONS

Cefpodoxime demonstrates good in vitro activity against pathogens frequently associated with respiratory tract, urinary tract, and skin and tissue infections. It has not demonstrated greater efficacy than the other antibiotics to which it has been compared. The available published clinical trials are fraught with methodologic, statistical, and evaluative flaws. Thus, further trials comparing cefpodoxime with established treatments, as well as the newer cephalosporins, are needed before its place in therapy can be established.

Authors+Show Affiliations

College of Pharmacy, University of Texas, Austin 78712.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8286813

Citation

Chocas, E C., et al. "Cefpodoxime Proxetil: a New, Broad-spectrum, Oral Cephalosporin." The Annals of Pharmacotherapy, vol. 27, no. 11, 1993, pp. 1369-77.
Chocas EC, Paap CM, Godley PJ. Cefpodoxime proxetil: a new, broad-spectrum, oral cephalosporin. Ann Pharmacother. 1993;27(11):1369-77.
Chocas, E. C., Paap, C. M., & Godley, P. J. (1993). Cefpodoxime proxetil: a new, broad-spectrum, oral cephalosporin. The Annals of Pharmacotherapy, 27(11), 1369-77.
Chocas EC, Paap CM, Godley PJ. Cefpodoxime Proxetil: a New, Broad-spectrum, Oral Cephalosporin. Ann Pharmacother. 1993;27(11):1369-77. PubMed PMID: 8286813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cefpodoxime proxetil: a new, broad-spectrum, oral cephalosporin. AU - Chocas,E C, AU - Paap,C M, AU - Godley,P J, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 1369 EP - 77 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 27 IS - 11 N2 - OBJECTIVE: To discuss the chemistry, pharmacokinetics, spectrum of activity, clinical trials, adverse effects, drug interactions, and dosage guidelines of cefpodoxime proxetil. DATA SOURCES: Literature was identified through a MEDLINE search from 1988 to the present and from review of bibliographies in that literature. STUDY SELECTION: Data were limited to comparative trials published in the English literature. Although many studies were conducted in Japan, the results often were available only in Japanese or partly in English. As these studies could not be completely evaluated, they are not included in this review. DATA SYNTHESIS: Cefpodoxime exhibits good activity against many gram-positive and gram-negative organisms. In clinical trials, cefpodoxime was similar in both clinical and bacteriologic efficacy to amoxicillin, cefaclor, amoxicillin/clavulanate, and penicillin in the treatment of respiratory and urinary tract infections. It also appeared effective in the treatment of skin and soft tissue infections, although no comparative trials have been performed. Cefpodoxime is well tolerated by children and is effective in the treatment of otitis media and pharyngitis. It has a similar adverse effect profile to that of other penicillins and cephalosporins, with gastrointestinal effects being most common. CONCLUSIONS: Cefpodoxime demonstrates good in vitro activity against pathogens frequently associated with respiratory tract, urinary tract, and skin and tissue infections. It has not demonstrated greater efficacy than the other antibiotics to which it has been compared. The available published clinical trials are fraught with methodologic, statistical, and evaluative flaws. Thus, further trials comparing cefpodoxime with established treatments, as well as the newer cephalosporins, are needed before its place in therapy can be established. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/8286813/Cefpodoxime_proxetil:_a_new_broad_spectrum_oral_cephalosporin_ L2 - https://journals.sagepub.com/doi/10.1177/106002809302701111?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -