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Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture.
Cancer Lett 1993; 74(1-2):85-90CL

Abstract

Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds (S-allyl-cysteine, S-ethyl-cysteine and S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells when added to cultures at 1.0 mM or less. However, oil-soluble organosulfur compounds (diallyl sulfide, diallyl disulfide and diallyl trisulfide) markedly inhibited growth. Increasing addition of diallyl disulfide (DADS) resulted in a progressive decrease in CMT-13 cell growth. Addition of glutathione before DADS markedly decreased the severity of the growth inhibition. Treatment with DL-buthionine-SR-sulfoxamine, a specific inhibitor of glutathione synthesis, accentuated the growth inhibition caused by DADS. These studies show that some organosulfur compounds found in garlic are effective inhibitors of the growth of the neoplastic CMT-13 cell. The inhibitory effects of these compounds are modified by intracellular glutathione.

Authors+Show Affiliations

Department of Nutrition, Pennsylvania State University, University Park 16802.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8287376

Citation

Sundaram, S G., and J A. Milner. "Impact of Organosulfur Compounds in Garlic On Canine Mammary Tumor Cells in Culture." Cancer Letters, vol. 74, no. 1-2, 1993, pp. 85-90.
Sundaram SG, Milner JA. Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Lett. 1993;74(1-2):85-90.
Sundaram, S. G., & Milner, J. A. (1993). Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Letters, 74(1-2), pp. 85-90.
Sundaram SG, Milner JA. Impact of Organosulfur Compounds in Garlic On Canine Mammary Tumor Cells in Culture. Cancer Lett. 1993 Oct 15;74(1-2):85-90. PubMed PMID: 8287376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. AU - Sundaram,S G, AU - Milner,J A, PY - 1993/10/15/pubmed PY - 1993/10/15/medline PY - 1993/10/15/entrez SP - 85 EP - 90 JF - Cancer letters JO - Cancer Lett. VL - 74 IS - 1-2 N2 - Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds (S-allyl-cysteine, S-ethyl-cysteine and S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells when added to cultures at 1.0 mM or less. However, oil-soluble organosulfur compounds (diallyl sulfide, diallyl disulfide and diallyl trisulfide) markedly inhibited growth. Increasing addition of diallyl disulfide (DADS) resulted in a progressive decrease in CMT-13 cell growth. Addition of glutathione before DADS markedly decreased the severity of the growth inhibition. Treatment with DL-buthionine-SR-sulfoxamine, a specific inhibitor of glutathione synthesis, accentuated the growth inhibition caused by DADS. These studies show that some organosulfur compounds found in garlic are effective inhibitors of the growth of the neoplastic CMT-13 cell. The inhibitory effects of these compounds are modified by intracellular glutathione. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/8287376/Impact_of_organosulfur_compounds_in_garlic_on_canine_mammary_tumor_cells_in_culture_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-3835(93)90048-E DB - PRIME DP - Unbound Medicine ER -