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Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture.

Abstract

Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds (S-allyl-cysteine, S-ethyl-cysteine and S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells when added to cultures at 1.0 mM or less. However, oil-soluble organosulfur compounds (diallyl sulfide, diallyl disulfide and diallyl trisulfide) markedly inhibited growth. Increasing addition of diallyl disulfide (DADS) resulted in a progressive decrease in CMT-13 cell growth. Addition of glutathione before DADS markedly decreased the severity of the growth inhibition. Treatment with DL-buthionine-SR-sulfoxamine, a specific inhibitor of glutathione synthesis, accentuated the growth inhibition caused by DADS. These studies show that some organosulfur compounds found in garlic are effective inhibitors of the growth of the neoplastic CMT-13 cell. The inhibitory effects of these compounds are modified by intracellular glutathione.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Nutrition, Pennsylvania State University, University Park 16802.

    Source

    Cancer letters 74:1-2 1993 Oct 15 pg 85-90

    MeSH

    Allyl Compounds
    Analysis of Variance
    Animals
    Anticarcinogenic Agents
    Cell Division
    Cysteine
    Disulfides
    Dogs
    Female
    Garlic
    Glutathione
    Growth Inhibitors
    Mammary Neoplasms, Experimental
    Plant Oils
    Plants, Medicinal
    Sulfides
    Sulfur
    Tumor Cells, Cultured

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8287376

    Citation

    Sundaram, S G., and J A. Milner. "Impact of Organosulfur Compounds in Garlic On Canine Mammary Tumor Cells in Culture." Cancer Letters, vol. 74, no. 1-2, 1993, pp. 85-90.
    Sundaram SG, Milner JA. Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Lett. 1993;74(1-2):85-90.
    Sundaram, S. G., & Milner, J. A. (1993). Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Letters, 74(1-2), pp. 85-90.
    Sundaram SG, Milner JA. Impact of Organosulfur Compounds in Garlic On Canine Mammary Tumor Cells in Culture. Cancer Lett. 1993 Oct 15;74(1-2):85-90. PubMed PMID: 8287376.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. AU - Sundaram,S G, AU - Milner,J A, PY - 1993/10/15/pubmed PY - 1993/10/15/medline PY - 1993/10/15/entrez SP - 85 EP - 90 JF - Cancer letters JO - Cancer Lett. VL - 74 IS - 1-2 N2 - Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds (S-allyl-cysteine, S-ethyl-cysteine and S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells when added to cultures at 1.0 mM or less. However, oil-soluble organosulfur compounds (diallyl sulfide, diallyl disulfide and diallyl trisulfide) markedly inhibited growth. Increasing addition of diallyl disulfide (DADS) resulted in a progressive decrease in CMT-13 cell growth. Addition of glutathione before DADS markedly decreased the severity of the growth inhibition. Treatment with DL-buthionine-SR-sulfoxamine, a specific inhibitor of glutathione synthesis, accentuated the growth inhibition caused by DADS. These studies show that some organosulfur compounds found in garlic are effective inhibitors of the growth of the neoplastic CMT-13 cell. The inhibitory effects of these compounds are modified by intracellular glutathione. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/8287376/Impact_of_organosulfur_compounds_in_garlic_on_canine_mammary_tumor_cells_in_culture_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-3835(93)90048-E DB - PRIME DP - Unbound Medicine ER -