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Gamma delta T cell receptor subsets in the lung of patients with HIV-1 infection.
Cell Immunol. 1994 Jan; 153(1):194-205.CI

Abstract

In this study the frequency of gamma delta+ cells and their subsets has been assessed in bronchoalveolar lavage (BAL) cell populations recovered from 51 patients at various clinical stages of HIV-1 infection. Thirteen out of the 51 HIV-1-infected patients showed an increase in the percentage of TCR delta 1+ BAL T cells (25.5%). BAL lymphocytes bearing pan-gamma delta antigens were also quantitatively increased in 10 patients (19.6%). A strict correlation was observed between the degree of CD8 alveolitis and the increase of gamma delta T cells. Phenotypic study of BAL gamma delta cells revealed that (a) V delta 2-related BB3+ cells accounted for the majority of lung gamma delta T cells; (b) these cells were CD45RO+ memory cells and expressed a series of adhesion molecules; and (c) 29% of BAL gamma delta T cells expressed CD8 surface molecules. We also compared the distribution of V delta 2 and V delta 1 subsets in paired samples of peripheral blood and BAL fluid. Patients who showed an increased number of BB3+ cells in the BAL fluid presented a reversal of the V delta 2 to V delta 1 cell ratio in the peripheral blood. By contrast, in the lung of normal subjects pulmonary BB3+ and A13+ cells were present in approximately the same proportions found in the peripheral blood. Taken together these data demonstrate that a redistribution of T cells expressing V delta 2 TCR takes place in the lung of a subset of patients with HIV-1 infection and CD8 alveolitis. In the pulmonary microenvironment these cells might play a role in the local immune response against HIV-1 and/or opportunistic infections.

Authors+Show Affiliations

Department of Clinical Medicine, Padua University School of Medicine, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8287489

Citation

Agostini, C, et al. "Gamma Delta T Cell Receptor Subsets in the Lung of Patients With HIV-1 Infection." Cellular Immunology, vol. 153, no. 1, 1994, pp. 194-205.
Agostini C, Zambello R, Trentin L, et al. Gamma delta T cell receptor subsets in the lung of patients with HIV-1 infection. Cell Immunol. 1994;153(1):194-205.
Agostini, C., Zambello, R., Trentin, L., Cerutti, A., Bulian, P., Crivellaro, C., Cipriani, A., & Semenzato, G. (1994). Gamma delta T cell receptor subsets in the lung of patients with HIV-1 infection. Cellular Immunology, 153(1), 194-205.
Agostini C, et al. Gamma Delta T Cell Receptor Subsets in the Lung of Patients With HIV-1 Infection. Cell Immunol. 1994;153(1):194-205. PubMed PMID: 8287489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gamma delta T cell receptor subsets in the lung of patients with HIV-1 infection. AU - Agostini,C, AU - Zambello,R, AU - Trentin,L, AU - Cerutti,A, AU - Bulian,P, AU - Crivellaro,C, AU - Cipriani,A, AU - Semenzato,G, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 194 EP - 205 JF - Cellular immunology JO - Cell Immunol VL - 153 IS - 1 N2 - In this study the frequency of gamma delta+ cells and their subsets has been assessed in bronchoalveolar lavage (BAL) cell populations recovered from 51 patients at various clinical stages of HIV-1 infection. Thirteen out of the 51 HIV-1-infected patients showed an increase in the percentage of TCR delta 1+ BAL T cells (25.5%). BAL lymphocytes bearing pan-gamma delta antigens were also quantitatively increased in 10 patients (19.6%). A strict correlation was observed between the degree of CD8 alveolitis and the increase of gamma delta T cells. Phenotypic study of BAL gamma delta cells revealed that (a) V delta 2-related BB3+ cells accounted for the majority of lung gamma delta T cells; (b) these cells were CD45RO+ memory cells and expressed a series of adhesion molecules; and (c) 29% of BAL gamma delta T cells expressed CD8 surface molecules. We also compared the distribution of V delta 2 and V delta 1 subsets in paired samples of peripheral blood and BAL fluid. Patients who showed an increased number of BB3+ cells in the BAL fluid presented a reversal of the V delta 2 to V delta 1 cell ratio in the peripheral blood. By contrast, in the lung of normal subjects pulmonary BB3+ and A13+ cells were present in approximately the same proportions found in the peripheral blood. Taken together these data demonstrate that a redistribution of T cells expressing V delta 2 TCR takes place in the lung of a subset of patients with HIV-1 infection and CD8 alveolitis. In the pulmonary microenvironment these cells might play a role in the local immune response against HIV-1 and/or opportunistic infections. SN - 0008-8749 UR - https://www.unboundmedicine.com/medline/citation/8287489/Gamma_delta_T_cell_receptor_subsets_in_the_lung_of_patients_with_HIV_1_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-8749(84)71017-3 DB - PRIME DP - Unbound Medicine ER -