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Measles, mumps, rubella vaccine administration in egg-sensitive children: systemic reactions during vaccine desensitization.
Ann Allergy 1994; 72(1):25-8AA

Abstract

In egg-sensitive children, measles-mumps-rubella (MMR) vaccination may cause acute allergic reactions; therefore, current recommendations are to perform skin testing with the commercial vaccine before administration to egg-allergic children. In children with positive skin tests, desensitization with the measles-mumps-rubella vaccine should be done in order to administer a full dose of the vaccine. Twelve egg-allergic children, aged 12 months to 5 years of age, were referred to our pediatric allergy clinic for MMR administration over a 20-month period. Three children had positive skin prick or intradermal tests to the MMR vaccine. Two of these three patients experienced systemic hypersensitivity reactions while undergoing desensitization to the MMR. All reactions occurred with injections of the undiluted vaccine. Based upon this experience, we recommend that egg-allergic children should continue to have cutaneous tests done to the MMR vaccine and careful observation during desensitization in those children with positive skin tests.

Authors+Show Affiliations

Department of Pediatrics, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8291745

Citation

Trotter, A C., et al. "Measles, Mumps, Rubella Vaccine Administration in Egg-sensitive Children: Systemic Reactions During Vaccine Desensitization." Annals of Allergy, vol. 72, no. 1, 1994, pp. 25-8.
Trotter AC, Stone BD, Laszlo DJ, et al. Measles, mumps, rubella vaccine administration in egg-sensitive children: systemic reactions during vaccine desensitization. Ann Allergy. 1994;72(1):25-8.
Trotter, A. C., Stone, B. D., Laszlo, D. J., & Georgitis, J. W. (1994). Measles, mumps, rubella vaccine administration in egg-sensitive children: systemic reactions during vaccine desensitization. Annals of Allergy, 72(1), pp. 25-8.
Trotter AC, et al. Measles, Mumps, Rubella Vaccine Administration in Egg-sensitive Children: Systemic Reactions During Vaccine Desensitization. Ann Allergy. 1994;72(1):25-8. PubMed PMID: 8291745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measles, mumps, rubella vaccine administration in egg-sensitive children: systemic reactions during vaccine desensitization. AU - Trotter,A C, AU - Stone,B D, AU - Laszlo,D J, AU - Georgitis,J W, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 25 EP - 8 JF - Annals of allergy JO - Ann Allergy VL - 72 IS - 1 N2 - In egg-sensitive children, measles-mumps-rubella (MMR) vaccination may cause acute allergic reactions; therefore, current recommendations are to perform skin testing with the commercial vaccine before administration to egg-allergic children. In children with positive skin tests, desensitization with the measles-mumps-rubella vaccine should be done in order to administer a full dose of the vaccine. Twelve egg-allergic children, aged 12 months to 5 years of age, were referred to our pediatric allergy clinic for MMR administration over a 20-month period. Three children had positive skin prick or intradermal tests to the MMR vaccine. Two of these three patients experienced systemic hypersensitivity reactions while undergoing desensitization to the MMR. All reactions occurred with injections of the undiluted vaccine. Based upon this experience, we recommend that egg-allergic children should continue to have cutaneous tests done to the MMR vaccine and careful observation during desensitization in those children with positive skin tests. SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/8291745/Measles_mumps_rubella_vaccine_administration_in_egg_sensitive_children:_systemic_reactions_during_vaccine_desensitization_ L2 - http://www.diseaseinfosearch.org/result/6369 DB - PRIME DP - Unbound Medicine ER -