Tags

Type your tag names separated by a space and hit enter

Lack of yohimbine effect on ambulatory blood pressure recording: a double-blind cross-over trial in parkinsonians with orthostatic hypotension.
Fundam Clin Pharmacol. 1993; 7(8):465-70.FC

Abstract

Yohimbine is an alpha 2-adrenergic antagonist which has been proposed for the treatment of orthostatic hypotension (OH). We investigated in a double-blind placebo-controlled crossover trial the effects of yohimbine (2 mg tid) on blood pressure (BP) and heart rate (HR) using ambulatory monitoring of blood pressure (AMBP) in 17 patients (69 +/- 5 years) with Parkinson's disease (PD) suffering from non drug-induced OH. At the end of each sequence of 4 weeks, mean systolic (SBP) and diastolic (DBP) BP and HR (+/- SD), BP variability (coefficient of variation of the mean) and nychtemeral rhythm were calculated for day-time (09:00-19:00 h) and night-time (23:00-06:00 h). OH related to PD was characterized by: i) loss of the nychtemeral rhythm of BP (night/day ratio: 1.18 +/- 0.14) but not of HR (night/day ratio: 0.87 +/- 0.04), ii) high variability of BP during day-time and iii) post-prandial hypotension (12 out of 17 patients). There was no significant difference in AMBP parameters between baseline, yohimbine and placebo periods. This study shows that AMBP is a simple and reproducible method to assess the effects of drugs used in the management of OH on BP parameters (mean values and variability) and that yohimbine is not effective to correct OH of PD. Future studies must investigate other more selective alpha 2-adrenergic antagonists.

Links

Publisher Full Text

Authors+Show Affiliations

Senard JM
Laboratoire de Pharmacologie Médicale et Clinique, INSERM U317, Faculté de Médecine, Toulouse, France.
Rascol O
No affiliation info available
Rascol A
No affiliation info available
Montastruc JL
No affiliation info available

MeSH

AgedAmbulatory CareBlood PressureBlood Pressure DeterminationDouble-Blind MethodFemaleHumansHypotension, OrthostaticMaleMiddle AgedMonitoring, PhysiologicParkinson Disease, SecondaryPlacebos

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8294084

Citation

Senard, J M., et al. "Lack of Yohimbine Effect On Ambulatory Blood Pressure Recording: a Double-blind Cross-over Trial in Parkinsonians With Orthostatic Hypotension." Fundamental & Clinical Pharmacology, vol. 7, no. 8, 1993, pp. 465-70.
Senard JM, Rascol O, Rascol A, et al. Lack of yohimbine effect on ambulatory blood pressure recording: a double-blind cross-over trial in parkinsonians with orthostatic hypotension. Fundam Clin Pharmacol. 1993;7(8):465-70.
Senard, J. M., Rascol, O., Rascol, A., & Montastruc, J. L. (1993). Lack of yohimbine effect on ambulatory blood pressure recording: a double-blind cross-over trial in parkinsonians with orthostatic hypotension. Fundamental & Clinical Pharmacology, 7(8), 465-70.
Senard JM, et al. Lack of Yohimbine Effect On Ambulatory Blood Pressure Recording: a Double-blind Cross-over Trial in Parkinsonians With Orthostatic Hypotension. Fundam Clin Pharmacol. 1993;7(8):465-70. PubMed PMID: 8294084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of yohimbine effect on ambulatory blood pressure recording: a double-blind cross-over trial in parkinsonians with orthostatic hypotension. AU - Senard,J M, AU - Rascol,O, AU - Rascol,A, AU - Montastruc,J L, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 465 EP - 70 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 7 IS - 8 N2 - Yohimbine is an alpha 2-adrenergic antagonist which has been proposed for the treatment of orthostatic hypotension (OH). We investigated in a double-blind placebo-controlled crossover trial the effects of yohimbine (2 mg tid) on blood pressure (BP) and heart rate (HR) using ambulatory monitoring of blood pressure (AMBP) in 17 patients (69 +/- 5 years) with Parkinson's disease (PD) suffering from non drug-induced OH. At the end of each sequence of 4 weeks, mean systolic (SBP) and diastolic (DBP) BP and HR (+/- SD), BP variability (coefficient of variation of the mean) and nychtemeral rhythm were calculated for day-time (09:00-19:00 h) and night-time (23:00-06:00 h). OH related to PD was characterized by: i) loss of the nychtemeral rhythm of BP (night/day ratio: 1.18 +/- 0.14) but not of HR (night/day ratio: 0.87 +/- 0.04), ii) high variability of BP during day-time and iii) post-prandial hypotension (12 out of 17 patients). There was no significant difference in AMBP parameters between baseline, yohimbine and placebo periods. This study shows that AMBP is a simple and reproducible method to assess the effects of drugs used in the management of OH on BP parameters (mean values and variability) and that yohimbine is not effective to correct OH of PD. Future studies must investigate other more selective alpha 2-adrenergic antagonists. SN - 0767-3981 UR - https://www.unboundmedicine.com/medline/citation/8294084/Lack_of_yohimbine_effect_on_ambulatory_blood_pressure_recording:_a_double_blind_cross_over_trial_in_parkinsonians_with_orthostatic_hypotension_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0767-3981&date=1993&volume=7&issue=8&spage=465 DB - PRIME DP - Unbound Medicine ER -