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Functional changes of the sciatic nerve in mice chronically infected with Trypanosoma cruzi.
Medicina (B Aires). 1993; 53(2):129-32.M

Abstract

Early histological studies carried out in the sciatic nerve of mice chronically infected with Trypanosoma cruzi showed demyelination and scanty axonal degeneration. The experiments reported in this paper were designed to assess the functional state of the sciatic nerve and of some of the muscles it supplies. For these purposes 14 mice were infected with trypomastigotes (clon K-98, CA-I strain) 12 months before the investigation. Results were compared with 13 normal mice matched by age and weight. Hamstring muscles were studied electromyographically by means of a fine coaxial needle electrode and the sciatic nerve action potential characteristics were recorded with surface electrodes. All the experiments were carried out in vivo. In the infected mice the electromyogram showed that some motor unit potentials has enlarged amplitude and duration and increased number of phases, suggesting that the size of their territories had been enlarged, probably through axonal collateral sproutings and reinnervation of muscle fibers previously relinquished by their original innervation. The sciatic nerve action potential of the infected animals showed diminished amplitude and prolonged latency. These features signal reduced number of functional axons within the nerve and demyelination of the remaining conducting fibers. These findings are in line with the histological evidences of the involvement of the peripheral nervous system in Chagas disease and give additional information about the functional state of the peripheral nerves in the experimental model.

Authors+Show Affiliations

División Neurología, Hospital Ramos Mejía, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8295529

Citation

Losavio, A S., et al. "Functional Changes of the Sciatic Nerve in Mice Chronically Infected With Trypanosoma Cruzi." Medicina, vol. 53, no. 2, 1993, pp. 129-32.
Losavio AS, Sica RE, Sanz OP, et al. Functional changes of the sciatic nerve in mice chronically infected with Trypanosoma cruzi. Medicina (B Aires). 1993;53(2):129-32.
Losavio, A. S., Sica, R. E., Sanz, O. P., Mirkin, G., González Cappa, S. M., & Muchnik, S. (1993). Functional changes of the sciatic nerve in mice chronically infected with Trypanosoma cruzi. Medicina, 53(2), 129-32.
Losavio AS, et al. Functional Changes of the Sciatic Nerve in Mice Chronically Infected With Trypanosoma Cruzi. Medicina (B Aires). 1993;53(2):129-32. PubMed PMID: 8295529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional changes of the sciatic nerve in mice chronically infected with Trypanosoma cruzi. AU - Losavio,A S, AU - Sica,R E, AU - Sanz,O P, AU - Mirkin,G, AU - González Cappa,S M, AU - Muchnik,S, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 129 EP - 32 JF - Medicina JO - Medicina (B Aires) VL - 53 IS - 2 N2 - Early histological studies carried out in the sciatic nerve of mice chronically infected with Trypanosoma cruzi showed demyelination and scanty axonal degeneration. The experiments reported in this paper were designed to assess the functional state of the sciatic nerve and of some of the muscles it supplies. For these purposes 14 mice were infected with trypomastigotes (clon K-98, CA-I strain) 12 months before the investigation. Results were compared with 13 normal mice matched by age and weight. Hamstring muscles were studied electromyographically by means of a fine coaxial needle electrode and the sciatic nerve action potential characteristics were recorded with surface electrodes. All the experiments were carried out in vivo. In the infected mice the electromyogram showed that some motor unit potentials has enlarged amplitude and duration and increased number of phases, suggesting that the size of their territories had been enlarged, probably through axonal collateral sproutings and reinnervation of muscle fibers previously relinquished by their original innervation. The sciatic nerve action potential of the infected animals showed diminished amplitude and prolonged latency. These features signal reduced number of functional axons within the nerve and demyelination of the remaining conducting fibers. These findings are in line with the histological evidences of the involvement of the peripheral nervous system in Chagas disease and give additional information about the functional state of the peripheral nerves in the experimental model. SN - 0025-7680 UR - https://www.unboundmedicine.com/medline/citation/8295529/Functional_changes_of_the_sciatic_nerve_in_mice_chronically_infected_with_Trypanosoma_cruzi_ L2 - https://medlineplus.gov/chagasdisease.html DB - PRIME DP - Unbound Medicine ER -