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Role of glucagon in human diabetic ketoacidosis: studies using somatostatin.
Clin Endocrinol (Oxf). 1976; 5 Suppl:299S-305S.CE

Abstract

The present studies demonstrate that endogenous glucagon is hyperglycaemic, lipolytic and ketogenic in man, and that insulin deficiency is necessary, but is in itself not sufficient, to cause fulminant diabetic ketoacidosis. Furthermore, continuous elevation of endogenous glucagon secretion appears to be necessary for the maintenance and continued development of the characteristic metabolic consequences of insulin lack.

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Authors

Gerich JE
No affiliation info available
Schneider VS
No affiliation info available
Lorenzi M
No affiliation info available
Tsalikian E
No affiliation info available
Karam JH
No affiliation info available
Bier DM
No affiliation info available
Forsham PH
No affiliation info available

MeSH

AdultAlanineBlood GlucoseDiabetes MellitusDiabetic KetoacidosisFatty Acids, NonesterifiedGlucagonHumansHydroxybutyratesInsulinMaleSomatostatin

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

829924

Citation

Gerich, J E., et al. "Role of Glucagon in Human Diabetic Ketoacidosis: Studies Using Somatostatin." Clinical Endocrinology, vol. 5 Suppl, 1976, 299S-305S.
Gerich JE, Schneider VS, Lorenzi M, et al. Role of glucagon in human diabetic ketoacidosis: studies using somatostatin. Clin Endocrinol (Oxf). 1976;5 Suppl:299S-305S.
Gerich, J. E., Schneider, V. S., Lorenzi, M., Tsalikian, E., Karam, J. H., Bier, D. M., & Forsham, P. H. (1976). Role of glucagon in human diabetic ketoacidosis: studies using somatostatin. Clinical Endocrinology, 5 Suppl, 299S-305S.
Gerich JE, et al. Role of Glucagon in Human Diabetic Ketoacidosis: Studies Using Somatostatin. Clin Endocrinol (Oxf). 1976;5 Suppl:299S-305S. PubMed PMID: 829924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of glucagon in human diabetic ketoacidosis: studies using somatostatin. AU - Gerich,J E, AU - Schneider,V S, AU - Lorenzi,M, AU - Tsalikian,E, AU - Karam,J H, AU - Bier,D M, AU - Forsham,P H, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 299S EP - 305S JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 5 Suppl N2 - The present studies demonstrate that endogenous glucagon is hyperglycaemic, lipolytic and ketogenic in man, and that insulin deficiency is necessary, but is in itself not sufficient, to cause fulminant diabetic ketoacidosis. Furthermore, continuous elevation of endogenous glucagon secretion appears to be necessary for the maintenance and continued development of the characteristic metabolic consequences of insulin lack. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/829924/Role_of_glucagon_in_human_diabetic_ketoacidosis:_studies_using_somatostatin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1976&volume=5&issue=&spage=299S DB - PRIME DP - Unbound Medicine ER -