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The effect of cyclosporin A on Angiostrongylus cantonensis infection and eosinophilia in mice.
Int J Parasitol. 1993 Dec; 23(8):997-1003.IJ

Abstract

Male BALB/c mice were infected with Angiostrongylus cantonensis and at various times p.i. treated with cyclosporin A (CsA) either for 5 days continuously or intermittently, or for 12-16 days on alternate days. They were monitored for peripheral blood eosinophilia and at necropsy examined for CSF and bone marrow eosinophilia, and worm recovery. CsA treatment provoked a transient inhibition of peripheral blood eosinophilia in all groups examined, followed by rebounding eosinophilia. There was no significant difference in bone marrow and CSF eosinophilia between CsA- and vehicle-treated groups. Mice treated with CsA on alternate days yielded lower intracranial worm recovery with small-sized worms at days 7, 21 and 30 p.i. than vehicle-treated groups did. No significant reduction in worm recovery was noted in mice treated for 5 days either continuously or intermittently, although worms, especially female ones, harvested from groups treated with CsA from days--1 to 3 or from days 13 to 17 were significantly smaller than those from vehicle-treated groups. CsA-treatment suppressed blastogenic responses of spleen cells against Con A or worm antigen at days 7 and 21 p.i. In vitro treatment of the 3rd stage larvae with CsA did not adversely influence survival of A. cantonensis in mice. These data indicate that CsA exerts anti-parasitic effects against A. cantonensis in mice.

Authors+Show Affiliations

Department of Parasitology, Akita University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8300308

Citation

Yoshimura, K, et al. "The Effect of Cyclosporin a On Angiostrongylus Cantonensis Infection and Eosinophilia in Mice." International Journal for Parasitology, vol. 23, no. 8, 1993, pp. 997-1003.
Yoshimura K, Sugaya H, Ishida K, et al. The effect of cyclosporin A on Angiostrongylus cantonensis infection and eosinophilia in mice. Int J Parasitol. 1993;23(8):997-1003.
Yoshimura, K., Sugaya, H., Ishida, K., Khan, W. I., Abe, T., & Unno, K. (1993). The effect of cyclosporin A on Angiostrongylus cantonensis infection and eosinophilia in mice. International Journal for Parasitology, 23(8), 997-1003.
Yoshimura K, et al. The Effect of Cyclosporin a On Angiostrongylus Cantonensis Infection and Eosinophilia in Mice. Int J Parasitol. 1993;23(8):997-1003. PubMed PMID: 8300308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of cyclosporin A on Angiostrongylus cantonensis infection and eosinophilia in mice. AU - Yoshimura,K, AU - Sugaya,H, AU - Ishida,K, AU - Khan,W I, AU - Abe,T, AU - Unno,K, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 997 EP - 1003 JF - International journal for parasitology JO - Int J Parasitol VL - 23 IS - 8 N2 - Male BALB/c mice were infected with Angiostrongylus cantonensis and at various times p.i. treated with cyclosporin A (CsA) either for 5 days continuously or intermittently, or for 12-16 days on alternate days. They were monitored for peripheral blood eosinophilia and at necropsy examined for CSF and bone marrow eosinophilia, and worm recovery. CsA treatment provoked a transient inhibition of peripheral blood eosinophilia in all groups examined, followed by rebounding eosinophilia. There was no significant difference in bone marrow and CSF eosinophilia between CsA- and vehicle-treated groups. Mice treated with CsA on alternate days yielded lower intracranial worm recovery with small-sized worms at days 7, 21 and 30 p.i. than vehicle-treated groups did. No significant reduction in worm recovery was noted in mice treated for 5 days either continuously or intermittently, although worms, especially female ones, harvested from groups treated with CsA from days--1 to 3 or from days 13 to 17 were significantly smaller than those from vehicle-treated groups. CsA-treatment suppressed blastogenic responses of spleen cells against Con A or worm antigen at days 7 and 21 p.i. In vitro treatment of the 3rd stage larvae with CsA did not adversely influence survival of A. cantonensis in mice. These data indicate that CsA exerts anti-parasitic effects against A. cantonensis in mice. SN - 0020-7519 UR - https://www.unboundmedicine.com/medline/citation/8300308/The_effect_of_cyclosporin_A_on_Angiostrongylus_cantonensis_infection_and_eosinophilia_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0020-7519(93)90119-J DB - PRIME DP - Unbound Medicine ER -