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Human milk secretory IgA antibody to nontypeable Haemophilus influenzae: possible protective effects against nasopharyngeal colonization.
J Pediatr. 1994 Feb; 124(2):193-8.JPed

Abstract

Sixty-eight children fed human milk were followed prospectively from birth to 12 months of age to assess the effect of milk antibody on nasopharyngeal colonization. Human milk secretory IgA antibody to P6, a highly conserved outer membrane protein of nontypeable Haemophilus influenzae, was measured with the use of an enzyme-linked immunosorbent assay. Nasopharyngeal colonization with nontypeable H. influenzae and the occurrence of otitis media were determined. Nasopharyngeal colonization was found in 22 children (32%), and 39 children (57%) had otitis media. Frequency of isolation of nontypeable H. influenzae was directly related to episodes of otitis media (r = 0.35; p = 0.001). The level of human milk anti-P6 secretory IgA antibody was inversely related to frequency of isolation of the organism (r = -0.27; p = 0.026). The average antibody level, expressed as nanograms per 0.1 mg total secretory IgA, in human milk fed to children with no colonization of nontypeable H. influenzae was significantly higher than in milk fed to children in whom colonization occurred on multiple occasions (156 +/- 120 vs 69 +/- 50; p = 0.013). Prevention of colonization was most evident during breast-feeding. These data suggest that the protective effects of human milk against otitis media may be due in part to inhibition of nasopharyngeal colonization with nontypeable H. influenzae by specific secretory IgA antibody.

Authors+Show Affiliations

Department of Pediatrics, School of Medicine, State University of New York at Buffalo.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8301421

Citation

Harabuchi, Y, et al. "Human Milk Secretory IgA Antibody to Nontypeable Haemophilus Influenzae: Possible Protective Effects Against Nasopharyngeal Colonization." The Journal of Pediatrics, vol. 124, no. 2, 1994, pp. 193-8.
Harabuchi Y, Faden H, Yamanaka N, et al. Human milk secretory IgA antibody to nontypeable Haemophilus influenzae: possible protective effects against nasopharyngeal colonization. J Pediatr. 1994;124(2):193-8.
Harabuchi, Y., Faden, H., Yamanaka, N., Duffy, L., Wolf, J., & Krystofik, D. (1994). Human milk secretory IgA antibody to nontypeable Haemophilus influenzae: possible protective effects against nasopharyngeal colonization. The Journal of Pediatrics, 124(2), 193-8.
Harabuchi Y, et al. Human Milk Secretory IgA Antibody to Nontypeable Haemophilus Influenzae: Possible Protective Effects Against Nasopharyngeal Colonization. J Pediatr. 1994;124(2):193-8. PubMed PMID: 8301421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human milk secretory IgA antibody to nontypeable Haemophilus influenzae: possible protective effects against nasopharyngeal colonization. AU - Harabuchi,Y, AU - Faden,H, AU - Yamanaka,N, AU - Duffy,L, AU - Wolf,J, AU - Krystofik,D, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 193 EP - 8 JF - The Journal of pediatrics JO - J Pediatr VL - 124 IS - 2 N2 - Sixty-eight children fed human milk were followed prospectively from birth to 12 months of age to assess the effect of milk antibody on nasopharyngeal colonization. Human milk secretory IgA antibody to P6, a highly conserved outer membrane protein of nontypeable Haemophilus influenzae, was measured with the use of an enzyme-linked immunosorbent assay. Nasopharyngeal colonization with nontypeable H. influenzae and the occurrence of otitis media were determined. Nasopharyngeal colonization was found in 22 children (32%), and 39 children (57%) had otitis media. Frequency of isolation of nontypeable H. influenzae was directly related to episodes of otitis media (r = 0.35; p = 0.001). The level of human milk anti-P6 secretory IgA antibody was inversely related to frequency of isolation of the organism (r = -0.27; p = 0.026). The average antibody level, expressed as nanograms per 0.1 mg total secretory IgA, in human milk fed to children with no colonization of nontypeable H. influenzae was significantly higher than in milk fed to children in whom colonization occurred on multiple occasions (156 +/- 120 vs 69 +/- 50; p = 0.013). Prevention of colonization was most evident during breast-feeding. These data suggest that the protective effects of human milk against otitis media may be due in part to inhibition of nasopharyngeal colonization with nontypeable H. influenzae by specific secretory IgA antibody. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/8301421/Human_milk_secretory_IgA_antibody_to_nontypeable_Haemophilus_influenzae:_possible_protective_effects_against_nasopharyngeal_colonization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022347694003264 DB - PRIME DP - Unbound Medicine ER -