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Mucosal melanoma of the head and neck: the impact of local control on survival.
Laryngoscope. 1994 Feb; 104(2):121-6.L

Abstract

The management for mucosal melanoma of the head and neck is controversial in view of the poor prognosis. Thirty-five patients seen from 1955 to 1991 were analyzed retrospectively. Almost all (34/35) presented with localized disease. Primary treatments included radical surgery (15), local resection (11), radiation therapy (6), or systemic treatment (2). While the rate of local recurrence was high (27/34), only 5 patients developed distant disease before local relapse. Furthermore, only 5/21 achieved successful local salvage. Patients with their disease controlled locally had significantly longer survival than those with persistent local disease (P = .0001). The 5-year disease-specific survival was 45%. The authors conclude that mucosal melanoma of the head and neck is not necessarily incurable. When local control is achieved, survival rate is significantly improved. Aggressive local treatments should be initiated at presentation of this disease.

Authors+Show Affiliations

Department of Radiation Oncology, University of California, Los Angeles 90024-6951.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8302112

Citation

Lee, S P., et al. "Mucosal Melanoma of the Head and Neck: the Impact of Local Control On Survival." The Laryngoscope, vol. 104, no. 2, 1994, pp. 121-6.
Lee SP, Shimizu KT, Tran LM, et al. Mucosal melanoma of the head and neck: the impact of local control on survival. Laryngoscope. 1994;104(2):121-6.
Lee, S. P., Shimizu, K. T., Tran, L. M., Juillard, G., & Calcaterra, T. C. (1994). Mucosal melanoma of the head and neck: the impact of local control on survival. The Laryngoscope, 104(2), 121-6.
Lee SP, et al. Mucosal Melanoma of the Head and Neck: the Impact of Local Control On Survival. Laryngoscope. 1994;104(2):121-6. PubMed PMID: 8302112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucosal melanoma of the head and neck: the impact of local control on survival. AU - Lee,S P, AU - Shimizu,K T, AU - Tran,L M, AU - Juillard,G, AU - Calcaterra,T C, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 121 EP - 6 JF - The Laryngoscope JO - Laryngoscope VL - 104 IS - 2 N2 - The management for mucosal melanoma of the head and neck is controversial in view of the poor prognosis. Thirty-five patients seen from 1955 to 1991 were analyzed retrospectively. Almost all (34/35) presented with localized disease. Primary treatments included radical surgery (15), local resection (11), radiation therapy (6), or systemic treatment (2). While the rate of local recurrence was high (27/34), only 5 patients developed distant disease before local relapse. Furthermore, only 5/21 achieved successful local salvage. Patients with their disease controlled locally had significantly longer survival than those with persistent local disease (P = .0001). The 5-year disease-specific survival was 45%. The authors conclude that mucosal melanoma of the head and neck is not necessarily incurable. When local control is achieved, survival rate is significantly improved. Aggressive local treatments should be initiated at presentation of this disease. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/8302112/Mucosal_melanoma_of_the_head_and_neck:_the_impact_of_local_control_on_survival_ L2 - https://doi.org/10.1288/00005537-199402000-00001 DB - PRIME DP - Unbound Medicine ER -