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Reserpine inhibits the NaK ATPase activity of the stria vascularis in the cochlea.
Laryngoscope. 1994 Feb; 104(2):197-200.L

Abstract

The function of the stria vascularis in the cochlea is believed to be the production of endolymph. The mechanisms that maintain or control the function of the stria vascularis, however, remain unclear. In the present study, the effects of one-shot reserpine administration on the NaK ATPase activity of the stria vascularis in guinea pigs were investigated. NaK ATPase activity was shown to be completely inhibited 3 to 20 days after reserpinization, and was detectable again 60 days after reserpinization. As reserpine is an adrenergic neuron blocker, these results suggest that catecholamines may play an essential role in the maintenance or control of NaK ATPase activity, and that the stria vascularis may be one of the target organs of catecholamines.

Authors+Show Affiliations

Department of Otolaryngology, Hyogo College of Medicine, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8302124

Citation

Kanoh, N. "Reserpine Inhibits the NaK ATPase Activity of the Stria Vascularis in the Cochlea." The Laryngoscope, vol. 104, no. 2, 1994, pp. 197-200.
Kanoh N. Reserpine inhibits the NaK ATPase activity of the stria vascularis in the cochlea. Laryngoscope. 1994;104(2):197-200.
Kanoh, N. (1994). Reserpine inhibits the NaK ATPase activity of the stria vascularis in the cochlea. The Laryngoscope, 104(2), 197-200.
Kanoh N. Reserpine Inhibits the NaK ATPase Activity of the Stria Vascularis in the Cochlea. Laryngoscope. 1994;104(2):197-200. PubMed PMID: 8302124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reserpine inhibits the NaK ATPase activity of the stria vascularis in the cochlea. A1 - Kanoh,N, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 197 EP - 200 JF - The Laryngoscope JO - Laryngoscope VL - 104 IS - 2 N2 - The function of the stria vascularis in the cochlea is believed to be the production of endolymph. The mechanisms that maintain or control the function of the stria vascularis, however, remain unclear. In the present study, the effects of one-shot reserpine administration on the NaK ATPase activity of the stria vascularis in guinea pigs were investigated. NaK ATPase activity was shown to be completely inhibited 3 to 20 days after reserpinization, and was detectable again 60 days after reserpinization. As reserpine is an adrenergic neuron blocker, these results suggest that catecholamines may play an essential role in the maintenance or control of NaK ATPase activity, and that the stria vascularis may be one of the target organs of catecholamines. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/8302124/Reserpine_inhibits_the_NaK_ATPase_activity_of_the_stria_vascularis_in_the_cochlea_ L2 - https://doi.org/10.1288/00005537-199402000-00013 DB - PRIME DP - Unbound Medicine ER -