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Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration.
Arterioscler Thromb. 1994 Feb; 14(2):193-8.AT

Abstract

Ischemic heart disease is caused by a combination of and interaction between a number of genetic and environmental factors. In a study of a group of healthy men from the United Kingdom, such an interaction was identified between the levels of plasma triglycerides and genetic variation determining plasma levels of factor VII, a clotting factor that is associated with risk of ischemic heart disease. We previously reported a common genetic polymorphism of the factor VII gene that changes arginine at residue 353 to a glutamine (Arg353-->Gln) and showed that healthy men who carry the allele for Gln353 had lower plasma levels of factor VII coagulant activity. This association is strongly confirmed in a new sample. Compared with 301 men with the allele for Arg353, 63 men with one or two alleles for Gln353 had levels of factor VII coagulant activity that were 20% lower (97.8% [95% confidence interval (CI), 95.2% to 100.4%] and 78.2% [CI, 73.8% to 82.9%], respectively; P < .0001), with similar genotype-associated differences observed for levels of factor VII antigen. The 6 men who were homozygous for the Gln353 allele had mean levels of factor VII coagulant activity and antigen that were lower by 40% and 50%, respectively. In an assay using bovine thromboplastin, which is specific for the cleaved (activated) form of factor VII, they had levels lower by 60%, suggesting that the major effect of the Gln353 substitution is to reduce the proportion of the circulating zymogen that is activated.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, University College London Medical School, Rayne Institute, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8305408

Citation

Humphries, S E., et al. "Factor VII Coagulant Activity and Antigen Levels in Healthy Men Are Determined By Interaction Between Factor VII Genotype and Plasma Triglyceride Concentration." Arteriosclerosis and Thrombosis : a Journal of Vascular Biology, vol. 14, no. 2, 1994, pp. 193-8.
Humphries SE, Lane A, Green FR, et al. Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration. Arterioscler Thromb. 1994;14(2):193-8.
Humphries, S. E., Lane, A., Green, F. R., Cooper, J., & Miller, G. J. (1994). Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology, 14(2), 193-8.
Humphries SE, et al. Factor VII Coagulant Activity and Antigen Levels in Healthy Men Are Determined By Interaction Between Factor VII Genotype and Plasma Triglyceride Concentration. Arterioscler Thromb. 1994;14(2):193-8. PubMed PMID: 8305408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration. AU - Humphries,S E, AU - Lane,A, AU - Green,F R, AU - Cooper,J, AU - Miller,G J, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 193 EP - 8 JF - Arteriosclerosis and thrombosis : a journal of vascular biology JO - Arterioscler Thromb VL - 14 IS - 2 N2 - Ischemic heart disease is caused by a combination of and interaction between a number of genetic and environmental factors. In a study of a group of healthy men from the United Kingdom, such an interaction was identified between the levels of plasma triglycerides and genetic variation determining plasma levels of factor VII, a clotting factor that is associated with risk of ischemic heart disease. We previously reported a common genetic polymorphism of the factor VII gene that changes arginine at residue 353 to a glutamine (Arg353-->Gln) and showed that healthy men who carry the allele for Gln353 had lower plasma levels of factor VII coagulant activity. This association is strongly confirmed in a new sample. Compared with 301 men with the allele for Arg353, 63 men with one or two alleles for Gln353 had levels of factor VII coagulant activity that were 20% lower (97.8% [95% confidence interval (CI), 95.2% to 100.4%] and 78.2% [CI, 73.8% to 82.9%], respectively; P < .0001), with similar genotype-associated differences observed for levels of factor VII antigen. The 6 men who were homozygous for the Gln353 allele had mean levels of factor VII coagulant activity and antigen that were lower by 40% and 50%, respectively. In an assay using bovine thromboplastin, which is specific for the cleaved (activated) form of factor VII, they had levels lower by 60%, suggesting that the major effect of the Gln353 substitution is to reduce the proportion of the circulating zymogen that is activated.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1049-8834 UR - https://www.unboundmedicine.com/medline/citation/8305408/Factor_VII_coagulant_activity_and_antigen_levels_in_healthy_men_are_determined_by_interaction_between_factor_VII_genotype_and_plasma_triglyceride_concentration_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8305408.ui DB - PRIME DP - Unbound Medicine ER -