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Ranitidine for the prevention of complications following endoscopic sclerotherapy for esophageal varices.
J Assoc Physicians India. 1993 Sep; 41(9):584, 589.JA

Abstract

Thirty one patients with significant esophageal variceal bleed were allocated alternately to receive endoscopic sclerotherapy along with ranitidine 300 mg daily or endoscopic sclerotherapy alone till eradication of varices. The mean sclerotherapy sessions, time and volume of sclerosant required for obliteration of varices were similar for the two groups. The esophageal varices were eradicated in all the patients except three in sclerotherapy alone group. There was statistically significant reduction in frequency of post sclerotherapy mucosal ulcers (P < 0.05) after addition of ranitidine to sclerotherapy. Rebleeding was not only significantly reduced (P < 0.05) in the sclerotherapy with ranitidine group but was minor and did not even require blood transfusion. In sclerotherapy alone group rebleeding was controlled by surgery in two patients and one died due to massive bleeding. The results of this study suggest a beneficial role of ranitidine in reducing post sclerotherapy mucosal ulcers and rebleeding. This effect of ranitidine emphasises the role of acid-pepsin in pathogenesis of these ulcers and its associated morbidity.

Authors+Show Affiliations

Command Hospital (SC) Pune.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8307916

Citation

Kumar, A, et al. "Ranitidine for the Prevention of Complications Following Endoscopic Sclerotherapy for Esophageal Varices." The Journal of the Association of Physicians of India, vol. 41, no. 9, 1993, pp. 584, 589.
Kumar A, Mehta SR, Joshi V, et al. Ranitidine for the prevention of complications following endoscopic sclerotherapy for esophageal varices. J Assoc Physicians India. 1993;41(9):584, 589.
Kumar, A., Mehta, S. R., Joshi, V., Kasthuri, A. S., & Narayanan, V. A. (1993). Ranitidine for the prevention of complications following endoscopic sclerotherapy for esophageal varices. The Journal of the Association of Physicians of India, 41(9), 584, 589.
Kumar A, et al. Ranitidine for the Prevention of Complications Following Endoscopic Sclerotherapy for Esophageal Varices. J Assoc Physicians India. 1993;41(9):584, 589. PubMed PMID: 8307916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ranitidine for the prevention of complications following endoscopic sclerotherapy for esophageal varices. AU - Kumar,A, AU - Mehta,S R, AU - Joshi,V, AU - Kasthuri,A S, AU - Narayanan,V A, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 584, 589 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 41 IS - 9 N2 - Thirty one patients with significant esophageal variceal bleed were allocated alternately to receive endoscopic sclerotherapy along with ranitidine 300 mg daily or endoscopic sclerotherapy alone till eradication of varices. The mean sclerotherapy sessions, time and volume of sclerosant required for obliteration of varices were similar for the two groups. The esophageal varices were eradicated in all the patients except three in sclerotherapy alone group. There was statistically significant reduction in frequency of post sclerotherapy mucosal ulcers (P < 0.05) after addition of ranitidine to sclerotherapy. Rebleeding was not only significantly reduced (P < 0.05) in the sclerotherapy with ranitidine group but was minor and did not even require blood transfusion. In sclerotherapy alone group rebleeding was controlled by surgery in two patients and one died due to massive bleeding. The results of this study suggest a beneficial role of ranitidine in reducing post sclerotherapy mucosal ulcers and rebleeding. This effect of ranitidine emphasises the role of acid-pepsin in pathogenesis of these ulcers and its associated morbidity. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/8307916/Ranitidine_for_the_prevention_of_complications_following_endoscopic_sclerotherapy_for_esophageal_varices_ L2 - http://www.diseaseinfosearch.org/result/2658 DB - PRIME DP - Unbound Medicine ER -