Tags

Type your tag names separated by a space and hit enter

Effects of 3-month amino acid dialysis compared to dextrose dialysis in children on continuous ambulatory peritoneal dialysis.
Perit Dial Int. 1994; 14(1):34-41.PD

Abstract

OBJECTIVES

To compare the nutritional and biochemical effects of amino acid dialysis to dextrose dialysis in children receiving continuous ambulatory peritoneal dialysis (CAPD).

DESIGN

Prospective randomized crossover study.

SETTING

Pediatric Nephrology Unit in a tertiary care, teaching hospital of the University of Toronto.

PATIENTS

Seven children aged 0.7-16.5 years receiving CAPD. All patients had poor linear growth, with 5 patients showing evidence of energy deficit.

INTERVENTIONS

Each patient received either amino acid or dextrose dialysate for 3 months, then crossed over to the alternate regimen for a subsequent 3 months.

MAIN OUTCOME MEASURES

Nutritional and biochemical data were obtained on each patient during each dialysis regimen.

RESULTS

Analysis of the patients' nutritional data showed comparable weight gain with both regimens but no significant improvement in lean body mass with either regimen. Appetite improved in most patients during amino acid dialysis. Biochemical data during amino acid dialysis showed a tendency to higher plasma potassium and urea levels with no clinical side effects or worsening of acidosis; however, there was a reduced anion gap and increased total plasma protein, due mostly to a rise in plasma albumin and a smaller increase in immunoglobulins. With the exception of tryptophan, fasting amino acid levels at the start and end of amino acid dialysis did not show any significant change. An interesting phenomenon of early blunting of the rise in amino acid levels, following a single amino acid dialysate exchange, was noticed at the end of the amino acid dialysis period. This newly described phenomenon could have been due to tolerance or hepatic enzyme induction.

CONCLUSIONS

Overall amino acid dialysis was comparable to dextrose dialysis with no additional proven nutritional benefit, was equally effective in ultrafiltration and creatinine clearance, and produced no adverse clinical or biochemical effects.

Authors+Show Affiliations

Division of Paediatric Nephrology, Hospital for Sick Children, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8312411

Citation

Qamar, I U., et al. "Effects of 3-month Amino Acid Dialysis Compared to Dextrose Dialysis in Children On Continuous Ambulatory Peritoneal Dialysis." Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis, vol. 14, no. 1, 1994, pp. 34-41.
Qamar IU, Levin L, Balfe JW, et al. Effects of 3-month amino acid dialysis compared to dextrose dialysis in children on continuous ambulatory peritoneal dialysis. Perit Dial Int. 1994;14(1):34-41.
Qamar, I. U., Levin, L., Balfe, J. W., Balfe, J. A., Secker, D., & Zlotkin, S. (1994). Effects of 3-month amino acid dialysis compared to dextrose dialysis in children on continuous ambulatory peritoneal dialysis. Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis, 14(1), 34-41.
Qamar IU, et al. Effects of 3-month Amino Acid Dialysis Compared to Dextrose Dialysis in Children On Continuous Ambulatory Peritoneal Dialysis. Perit Dial Int. 1994;14(1):34-41. PubMed PMID: 8312411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of 3-month amino acid dialysis compared to dextrose dialysis in children on continuous ambulatory peritoneal dialysis. AU - Qamar,I U, AU - Levin,L, AU - Balfe,J W, AU - Balfe,J A, AU - Secker,D, AU - Zlotkin,S, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 34 EP - 41 JF - Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis JO - Perit Dial Int VL - 14 IS - 1 N2 - OBJECTIVES: To compare the nutritional and biochemical effects of amino acid dialysis to dextrose dialysis in children receiving continuous ambulatory peritoneal dialysis (CAPD). DESIGN: Prospective randomized crossover study. SETTING: Pediatric Nephrology Unit in a tertiary care, teaching hospital of the University of Toronto. PATIENTS: Seven children aged 0.7-16.5 years receiving CAPD. All patients had poor linear growth, with 5 patients showing evidence of energy deficit. INTERVENTIONS: Each patient received either amino acid or dextrose dialysate for 3 months, then crossed over to the alternate regimen for a subsequent 3 months. MAIN OUTCOME MEASURES: Nutritional and biochemical data were obtained on each patient during each dialysis regimen. RESULTS: Analysis of the patients' nutritional data showed comparable weight gain with both regimens but no significant improvement in lean body mass with either regimen. Appetite improved in most patients during amino acid dialysis. Biochemical data during amino acid dialysis showed a tendency to higher plasma potassium and urea levels with no clinical side effects or worsening of acidosis; however, there was a reduced anion gap and increased total plasma protein, due mostly to a rise in plasma albumin and a smaller increase in immunoglobulins. With the exception of tryptophan, fasting amino acid levels at the start and end of amino acid dialysis did not show any significant change. An interesting phenomenon of early blunting of the rise in amino acid levels, following a single amino acid dialysate exchange, was noticed at the end of the amino acid dialysis period. This newly described phenomenon could have been due to tolerance or hepatic enzyme induction. CONCLUSIONS: Overall amino acid dialysis was comparable to dextrose dialysis with no additional proven nutritional benefit, was equally effective in ultrafiltration and creatinine clearance, and produced no adverse clinical or biochemical effects. SN - 0896-8608 UR - https://www.unboundmedicine.com/medline/citation/8312411/Effects_of_3_month_amino_acid_dialysis_compared_to_dextrose_dialysis_in_children_on_continuous_ambulatory_peritoneal_dialysis_ L2 - http://www.pdiconnect.com/cgi/pmidlookup?view=long&pmid=8312411 DB - PRIME DP - Unbound Medicine ER -