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Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis.
Ear Nose Throat J. 1993 Dec; 72(12):804-10.EN

Abstract

A new macrolide drug, clarithromycin (Biaxin) was compared with amoxicillin/clavulanate (Augmentin) in a single-blind (investigator-blind), randomized, multicenter study of 497 outpatients with acute maxillary sinusitis; treatment was 500 mg clarithromycin bid (n = 246) or 500 mg amoxicillin/clavulanate tid (n = 251). Pathogens included Streptococcus pneumoniae in 22% of patients, Staphylococcus aureus in 16%, Haemophilus influenzae in 10%, and Moraxella catarrhalis in 7%. For evaluable patients, clinical success (cure or improvement) was noted for 97% (128/132) of clarithromycin recipients and 93% (119/128) amoxicillin/clavulanate recipients. Clinically significant improvement in signs and symptoms was comparable between groups. Bacteriologic cure rates were 87% (115/132) and 90% (115/128), respectively. Respective pathogen eradication rates were 87% (125/143) and 90% (125/139). Adverse events not due to concurrent conditions occurred in 41% of the former and 46% of the latter group; most were mild to moderate gastrointestinal upsets (21% and 38%, respectively; P < 0.001). We conclude that clarithromycin appears to be as effective as amoxicillin/clavulanate in acute maxillary sinusitis and may cause fewer gastrointestinal upsets.

Authors+Show Affiliations

Centre Hospitalier Hotel-Dieu, Sherbrooke, Quebec, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8313865

Citation

Dubois, J, et al. "Efficacy of Clarithromycin Vs. Amoxicillin/clavulanate in the Treatment of Acute Maxillary Sinusitis." Ear, Nose, & Throat Journal, vol. 72, no. 12, 1993, pp. 804-10.
Dubois J, Saint-Pierre C, Tremblay C. Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. Ear Nose Throat J. 1993;72(12):804-10.
Dubois, J., Saint-Pierre, C., & Tremblay, C. (1993). Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. Ear, Nose, & Throat Journal, 72(12), 804-10.
Dubois J, Saint-Pierre C, Tremblay C. Efficacy of Clarithromycin Vs. Amoxicillin/clavulanate in the Treatment of Acute Maxillary Sinusitis. Ear Nose Throat J. 1993;72(12):804-10. PubMed PMID: 8313865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. AU - Dubois,J, AU - Saint-Pierre,C, AU - Tremblay,C, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 804 EP - 10 JF - Ear, nose, & throat journal JO - Ear Nose Throat J VL - 72 IS - 12 N2 - A new macrolide drug, clarithromycin (Biaxin) was compared with amoxicillin/clavulanate (Augmentin) in a single-blind (investigator-blind), randomized, multicenter study of 497 outpatients with acute maxillary sinusitis; treatment was 500 mg clarithromycin bid (n = 246) or 500 mg amoxicillin/clavulanate tid (n = 251). Pathogens included Streptococcus pneumoniae in 22% of patients, Staphylococcus aureus in 16%, Haemophilus influenzae in 10%, and Moraxella catarrhalis in 7%. For evaluable patients, clinical success (cure or improvement) was noted for 97% (128/132) of clarithromycin recipients and 93% (119/128) amoxicillin/clavulanate recipients. Clinically significant improvement in signs and symptoms was comparable between groups. Bacteriologic cure rates were 87% (115/132) and 90% (115/128), respectively. Respective pathogen eradication rates were 87% (125/143) and 90% (125/139). Adverse events not due to concurrent conditions occurred in 41% of the former and 46% of the latter group; most were mild to moderate gastrointestinal upsets (21% and 38%, respectively; P < 0.001). We conclude that clarithromycin appears to be as effective as amoxicillin/clavulanate in acute maxillary sinusitis and may cause fewer gastrointestinal upsets. SN - 0145-5613 UR - https://www.unboundmedicine.com/medline/citation/8313865/Efficacy_of_clarithromycin_vs__amoxicillin/clavulanate_in_the_treatment_of_acute_maxillary_sinusitis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8313865.ui DB - PRIME DP - Unbound Medicine ER -