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Alcohol and gastric acid secretion in humans.
Gut. 1993 Jun; 34(6):843-7.Gut

Abstract

The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has either no effect or a mildly inhibitory one. Pure ethanol given by any route does not cause release of gastrin in humans. Alcoholic beverages with low ethanol content (beer and wine) are strong stimulants of gastric acid secretion and gastrin release, the effect of beer being equal to the maximal acid output. Beverages with a higher ethanol content (whisky, gin, cognac) do not stimulate gastric acid secretion or release of gastrin. The powerful stimulants of gastric acid secretion present in beer, which are yet to be identified, are thermostable and anionic polar substances. The effect of chronic alcohol abuse on gastric acid secretion is not as predictable. Chronic alcoholic patients may have normal, enhanced, or diminished acid secretory capacity; hypochlorhydria being associated histologically with atrophic gastritis. There are no studies on the acute effect of alcohol intake on gastric acid secretion in chronic alcoholic patients. The acid stimulatory component of beer and wine needs to be characterised and its possible role in the causation of alcohol induced gastrointestinal diseases needs to be investigated.

Authors+Show Affiliations

Department of Medicine IV (Gastroenterology), University Hospital of Heidelberg, Mannheim, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8314520

Citation

Chari, S, et al. "Alcohol and Gastric Acid Secretion in Humans." Gut, vol. 34, no. 6, 1993, pp. 843-7.
Chari S, Teyssen S, Singer MV. Alcohol and gastric acid secretion in humans. Gut. 1993;34(6):843-7.
Chari, S., Teyssen, S., & Singer, M. V. (1993). Alcohol and gastric acid secretion in humans. Gut, 34(6), 843-7.
Chari S, Teyssen S, Singer MV. Alcohol and Gastric Acid Secretion in Humans. Gut. 1993;34(6):843-7. PubMed PMID: 8314520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and gastric acid secretion in humans. AU - Chari,S, AU - Teyssen,S, AU - Singer,M V, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 843 EP - 7 JF - Gut JO - Gut VL - 34 IS - 6 N2 - The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has either no effect or a mildly inhibitory one. Pure ethanol given by any route does not cause release of gastrin in humans. Alcoholic beverages with low ethanol content (beer and wine) are strong stimulants of gastric acid secretion and gastrin release, the effect of beer being equal to the maximal acid output. Beverages with a higher ethanol content (whisky, gin, cognac) do not stimulate gastric acid secretion or release of gastrin. The powerful stimulants of gastric acid secretion present in beer, which are yet to be identified, are thermostable and anionic polar substances. The effect of chronic alcohol abuse on gastric acid secretion is not as predictable. Chronic alcoholic patients may have normal, enhanced, or diminished acid secretory capacity; hypochlorhydria being associated histologically with atrophic gastritis. There are no studies on the acute effect of alcohol intake on gastric acid secretion in chronic alcoholic patients. The acid stimulatory component of beer and wine needs to be characterised and its possible role in the causation of alcohol induced gastrointestinal diseases needs to be investigated. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/8314520/Alcohol_and_gastric_acid_secretion_in_humans_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&amp;pmid=8314520 DB - PRIME DP - Unbound Medicine ER -