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[Antiendomysium antibodies and antigliadin antibodies in diagnosis and follow-up of celiac disease].
Minerva Pediatr 1993 Jan-Feb; 45(1-2):29-33MP

Abstract

Anti-endomysium antibodies (AEA) and Antigliadin antibodies (AGA) have been compared in a group of coeliac patients (17 with untreated coeliac disease, 56 after gluten free diet and 14 after gluten challenge), in 69 patients with various intestinal pathological conditions, and in 40 healthy children, in order to appreciate sensitivity and specificity of these tests in diagnosis of coeliac disease. AEA and AGA IgA were detected in 100% and AGA IgG were found in 94.1% of coeliacs with untreated disease; after gluten free diet AGA IgG were found in 27.7% of cases, while AGA IgA and AEA were absent in all coeliacs but one with non correct compliance to diet. After gluten challenge followed by villous atrophy, 78.5% of patients were positive for AGA IgA, 85.71% for AGA IgG and 100% for AEA. Anti-endomysium antibodies were absent both in healthy controls both in control disease patients, while sometimes antigliadin antibodies were present in patients with various intestinal pathology (AGA IgA in 1.44% and AGA IgG in 7.2% of cases). In our experience therefore AEA, because their sensitivity and high specificity, appear to disclose new prospects in diagnosis of coeliac disease.

Authors+Show Affiliations

Clinica Pediatrica R, Università degli Studi di Palermo.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

8316160

Citation

Cataldo, F, et al. "[Antiendomysium Antibodies and Antigliadin Antibodies in Diagnosis and Follow-up of Celiac Disease]." Minerva Pediatrica, vol. 45, no. 1-2, 1993, pp. 29-33.
Cataldo F, Trippiedi MA, Marino V, et al. [Antiendomysium antibodies and antigliadin antibodies in diagnosis and follow-up of celiac disease]. Minerva Pediatr. 1993;45(1-2):29-33.
Cataldo, F., Trippiedi, M. A., Marino, V., Maltese, I., Traverso, G., Paternostro, D., & Albeggiani, A. (1993). [Antiendomysium antibodies and antigliadin antibodies in diagnosis and follow-up of celiac disease]. Minerva Pediatrica, 45(1-2), pp. 29-33.
Cataldo F, et al. [Antiendomysium Antibodies and Antigliadin Antibodies in Diagnosis and Follow-up of Celiac Disease]. Minerva Pediatr. 1993;45(1-2):29-33. PubMed PMID: 8316160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antiendomysium antibodies and antigliadin antibodies in diagnosis and follow-up of celiac disease]. AU - Cataldo,F, AU - Trippiedi,M A, AU - Marino,V, AU - Maltese,I, AU - Traverso,G, AU - Paternostro,D, AU - Albeggiani,A, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 29 EP - 33 JF - Minerva pediatrica JO - Minerva Pediatr. VL - 45 IS - 1-2 N2 - Anti-endomysium antibodies (AEA) and Antigliadin antibodies (AGA) have been compared in a group of coeliac patients (17 with untreated coeliac disease, 56 after gluten free diet and 14 after gluten challenge), in 69 patients with various intestinal pathological conditions, and in 40 healthy children, in order to appreciate sensitivity and specificity of these tests in diagnosis of coeliac disease. AEA and AGA IgA were detected in 100% and AGA IgG were found in 94.1% of coeliacs with untreated disease; after gluten free diet AGA IgG were found in 27.7% of cases, while AGA IgA and AEA were absent in all coeliacs but one with non correct compliance to diet. After gluten challenge followed by villous atrophy, 78.5% of patients were positive for AGA IgA, 85.71% for AGA IgG and 100% for AEA. Anti-endomysium antibodies were absent both in healthy controls both in control disease patients, while sometimes antigliadin antibodies were present in patients with various intestinal pathology (AGA IgA in 1.44% and AGA IgG in 7.2% of cases). In our experience therefore AEA, because their sensitivity and high specificity, appear to disclose new prospects in diagnosis of coeliac disease. SN - 0026-4946 UR - https://www.unboundmedicine.com/medline/citation/8316160/[Antiendomysium_antibodies_and_antigliadin_antibodies_in_diagnosis_and_follow_up_of_celiac_disease]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -