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Effects of citrate on the different phases of calcium oxalate crystallization.
Scanning Microsc 1993; 7(1):381-9; discussion 389-90SM

Abstract

Urinary citrate appears to be an important factor in the crystallization process of calcium oxalate and calcium phosphate. The urinary excretion of citrate was found to be significantly lower in patients with calcium oxalate stone disease as compared with normal subjects, and about 30 per cent of the calcium stone formers can be considered as hypocitraturic. The lowest excretion of citrate was recorded in urine collected during the night. Citrate has significant effects on supersaturation with respect to both calcium oxalate and calcium phosphate, it also inhibits the growth of these crystals. In addition, citrate appears to be capable of inhibiting the aggregation of crystals composed of calcium oxalate, brushite, and hydroxyapatite. The heterogenous growth of calcium oxalate on calcium phosphate is also counteracted by citrate. As a consequence of the crucial role of citrate in these processes, stone prevention with alkaline citrate has become an attractive form of treatment in patients with recurrent stone formation. Single evening dose administration of sodium potassium citrate resulted in an of sodium potassium citrate resulted in an increased excretion of citrate, reduced levels of the calcium/citrate ratio as well as supersaturation with respect to calcium oxalate and a decreased rate of stone formation. However, conflicting results of stone preventive treatment with alkaline citrate have been reported by different groups, and long-term follow-up of patients treated in a randomized way is necessary to definitely assess the efficacy of alkaline citrate.

Authors+Show Affiliations

Department of Urology, University Hospital, Linköping, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8316807

Citation

Tiselius, H G., et al. "Effects of Citrate On the Different Phases of Calcium Oxalate Crystallization." Scanning Microscopy, vol. 7, no. 1, 1993, pp. 381-9; discussion 389-90.
Tiselius HG, Berg C, Fornander AM, et al. Effects of citrate on the different phases of calcium oxalate crystallization. Scanning Microsc. 1993;7(1):381-9; discussion 389-90.
Tiselius, H. G., Berg, C., Fornander, A. M., & Nilsson, M. A. (1993). Effects of citrate on the different phases of calcium oxalate crystallization. Scanning Microscopy, 7(1), pp. 381-9; discussion 389-90.
Tiselius HG, et al. Effects of Citrate On the Different Phases of Calcium Oxalate Crystallization. Scanning Microsc. 1993;7(1):381-9; discussion 389-90. PubMed PMID: 8316807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of citrate on the different phases of calcium oxalate crystallization. AU - Tiselius,H G, AU - Berg,C, AU - Fornander,A M, AU - Nilsson,M A, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 381-9; discussion 389-90 JF - Scanning microscopy JO - Scanning Microsc. VL - 7 IS - 1 N2 - Urinary citrate appears to be an important factor in the crystallization process of calcium oxalate and calcium phosphate. The urinary excretion of citrate was found to be significantly lower in patients with calcium oxalate stone disease as compared with normal subjects, and about 30 per cent of the calcium stone formers can be considered as hypocitraturic. The lowest excretion of citrate was recorded in urine collected during the night. Citrate has significant effects on supersaturation with respect to both calcium oxalate and calcium phosphate, it also inhibits the growth of these crystals. In addition, citrate appears to be capable of inhibiting the aggregation of crystals composed of calcium oxalate, brushite, and hydroxyapatite. The heterogenous growth of calcium oxalate on calcium phosphate is also counteracted by citrate. As a consequence of the crucial role of citrate in these processes, stone prevention with alkaline citrate has become an attractive form of treatment in patients with recurrent stone formation. Single evening dose administration of sodium potassium citrate resulted in an of sodium potassium citrate resulted in an increased excretion of citrate, reduced levels of the calcium/citrate ratio as well as supersaturation with respect to calcium oxalate and a decreased rate of stone formation. However, conflicting results of stone preventive treatment with alkaline citrate have been reported by different groups, and long-term follow-up of patients treated in a randomized way is necessary to definitely assess the efficacy of alkaline citrate. SN - 0891-7035 UR - https://www.unboundmedicine.com/medline/citation/8316807/Effects_of_citrate_on_the_different_phases_of_calcium_oxalate_crystallization_ DB - PRIME DP - Unbound Medicine ER -