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Protection from intrauterine growth retardation in Tibetans at high altitude.
Am J Phys Anthropol 1993; 91(2):215-24AJ

Abstract

Intrauterine growth retardation has long been recognized at high altitude. Since growth-retarded babies have a decreased chance of survival, intrauterine growth retardation would be expected to have been selected against in populations long resident at high altitude. We have previously reported that Tibetan babies born at 3,658 m weighed more than their North or South American altitude counterparts. This study sought to determine whether Tibetans were protected from altitude-associated intrauterine growth retardation. We compared birth weights in Tibetans living at low altitude in Kathmandu, Nepal (elevation 1,200 m), or at high altitude in Lhasa, Tibet Autonomous Region, China (elevation 3,658 m). Birth weights were similar in 45 low-altitude and 34 high-altitude Tibetan births regardless of whether all infants or only full-term births were considered, or whether birth weight was adjusted for variation in maternal parity, gestational age, and infant sex. In comparison with literature observations, the altitude-associated difference in birth weight was smallest in Tibetans, intermediate in South America, and greatest in North America. These data support the hypothesis that Tibetans are protected from altitude-associated intrauterine growth retardation and suggest that selection for optimization of birth weight at high altitude has occurred in Tibetans.

Authors+Show Affiliations

Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8317562

Citation

Zamudio, S, et al. "Protection From Intrauterine Growth Retardation in Tibetans at High Altitude." American Journal of Physical Anthropology, vol. 91, no. 2, 1993, pp. 215-24.
Zamudio S, Droma T, Norkyel KY, et al. Protection from intrauterine growth retardation in Tibetans at high altitude. Am J Phys Anthropol. 1993;91(2):215-24.
Zamudio, S., Droma, T., Norkyel, K. Y., Acharya, G., Zamudio, J. A., Niermeyer, S. N., & Moore, L. G. (1993). Protection from intrauterine growth retardation in Tibetans at high altitude. American Journal of Physical Anthropology, 91(2), pp. 215-24.
Zamudio S, et al. Protection From Intrauterine Growth Retardation in Tibetans at High Altitude. Am J Phys Anthropol. 1993;91(2):215-24. PubMed PMID: 8317562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection from intrauterine growth retardation in Tibetans at high altitude. AU - Zamudio,S, AU - Droma,T, AU - Norkyel,K Y, AU - Acharya,G, AU - Zamudio,J A, AU - Niermeyer,S N, AU - Moore,L G, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez KW - Age Factors KW - Altitude KW - Americas KW - Asia KW - Biology KW - Birth Weight KW - Body Weight KW - Bolivia KW - Child Development KW - China KW - Colorado KW - Comparative Studies KW - Cross-cultural Comparisons KW - Demographic Factors KW - Developed Countries KW - Developing Countries KW - Eastern Asia KW - Fetus KW - Gestational Age KW - Growth KW - Infant KW - Latin America KW - Low Birth Weight KW - Nepal KW - North America KW - Northern America KW - Peru KW - Physiology KW - Population KW - Population Characteristics KW - Pregnancy KW - Reproduction KW - Research Report KW - South America KW - Southern Asia KW - Studies KW - United States KW - Youth SP - 215 EP - 24 JF - American journal of physical anthropology JO - Am. J. Phys. Anthropol. VL - 91 IS - 2 N2 - Intrauterine growth retardation has long been recognized at high altitude. Since growth-retarded babies have a decreased chance of survival, intrauterine growth retardation would be expected to have been selected against in populations long resident at high altitude. We have previously reported that Tibetan babies born at 3,658 m weighed more than their North or South American altitude counterparts. This study sought to determine whether Tibetans were protected from altitude-associated intrauterine growth retardation. We compared birth weights in Tibetans living at low altitude in Kathmandu, Nepal (elevation 1,200 m), or at high altitude in Lhasa, Tibet Autonomous Region, China (elevation 3,658 m). Birth weights were similar in 45 low-altitude and 34 high-altitude Tibetan births regardless of whether all infants or only full-term births were considered, or whether birth weight was adjusted for variation in maternal parity, gestational age, and infant sex. In comparison with literature observations, the altitude-associated difference in birth weight was smallest in Tibetans, intermediate in South America, and greatest in North America. These data support the hypothesis that Tibetans are protected from altitude-associated intrauterine growth retardation and suggest that selection for optimization of birth weight at high altitude has occurred in Tibetans. SN - 0002-9483 UR - https://www.unboundmedicine.com/medline/citation/8317562/Protection_from_intrauterine_growth_retardation_in_Tibetans_at_high_altitude_ L2 - https://doi.org/10.1002/ajpa.1330910207 DB - PRIME DP - Unbound Medicine ER -