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[Cisapride efficacy in gastroesophageal reflux in children].
Pediatr Med Chir 1993 Mar-Apr; 15(2):141-4PM

Abstract

In the last years gastroesophageal reflux disease received more attentions, due to an improving in diagnostic techniques. Motility disorders, such as reduced competence of lower esophageal sphincter, motor esophageal disorders, delayed gastric emptying are important factors in the pathogenesis of the disease. Therefore therapy using prokinetic agents has been considered useful. A variety of drugs such as bethanecol, metoclopramide and domperidone have been used. There are conflicting report on the effects of these drugs and it should also be emphasized that they are not devoid of side effects related to dopamine antagonism. Recently cisapride, prokinetic agent which acts through facilitation of acetylcholine release, has been considered effective and well tolerate drug for the treatment of gastroesophageal reflux disease. In this view we investigated the effects of oral administration of cisapride in 12 children (age range 3-40 months), 7 females and 5 males, suffering from gastroesophageal reflux disease diagnosed on the bases of: clinic criteria, barium swallow radiological examination, 24-hour intraesophageal pH monitoring. After diagnosis a treatment with cisapride (1 mg/kg/die) before feedings for 8 weeks was started in all children. At the end of the trial clinical assessment and 24-hour intraesophageal pH test were performed. Clinical assessment was determined through weight, length and a clinical score calculated using the following parameters: regurgitation, vomiting, irritability, nocturnal weeping, meteorism, respiratory complaints. The total score was evaluated at diagnosis and during the follow-up (1st, 2nd, 4th and 8th week).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

1 Clinica Pediatrica, Policlinico di Catania, Università di Catania, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

8321715

Citation

Bottaro, G, et al. "[Cisapride Efficacy in Gastroesophageal Reflux in Children]." La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, vol. 15, no. 2, 1993, pp. 141-4.
Bottaro G, Rotolo N, Spina M, et al. [Cisapride efficacy in gastroesophageal reflux in children]. Pediatr Med Chir. 1993;15(2):141-4.
Bottaro, G., Rotolo, N., Spina, M., Azzaro, F., Galletta, C., Romano, D., ... Patanè, R. (1993). [Cisapride efficacy in gastroesophageal reflux in children]. La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, 15(2), pp. 141-4.
Bottaro G, et al. [Cisapride Efficacy in Gastroesophageal Reflux in Children]. Pediatr Med Chir. 1993;15(2):141-4. PubMed PMID: 8321715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cisapride efficacy in gastroesophageal reflux in children]. AU - Bottaro,G, AU - Rotolo,N, AU - Spina,M, AU - Azzaro,F, AU - Galletta,C, AU - Romano,D, AU - Castiglione,N, AU - Patanè,R, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 141 EP - 4 JF - La Pediatria medica e chirurgica : Medical and surgical pediatrics JO - Pediatr Med Chir VL - 15 IS - 2 N2 - In the last years gastroesophageal reflux disease received more attentions, due to an improving in diagnostic techniques. Motility disorders, such as reduced competence of lower esophageal sphincter, motor esophageal disorders, delayed gastric emptying are important factors in the pathogenesis of the disease. Therefore therapy using prokinetic agents has been considered useful. A variety of drugs such as bethanecol, metoclopramide and domperidone have been used. There are conflicting report on the effects of these drugs and it should also be emphasized that they are not devoid of side effects related to dopamine antagonism. Recently cisapride, prokinetic agent which acts through facilitation of acetylcholine release, has been considered effective and well tolerate drug for the treatment of gastroesophageal reflux disease. In this view we investigated the effects of oral administration of cisapride in 12 children (age range 3-40 months), 7 females and 5 males, suffering from gastroesophageal reflux disease diagnosed on the bases of: clinic criteria, barium swallow radiological examination, 24-hour intraesophageal pH monitoring. After diagnosis a treatment with cisapride (1 mg/kg/die) before feedings for 8 weeks was started in all children. At the end of the trial clinical assessment and 24-hour intraesophageal pH test were performed. Clinical assessment was determined through weight, length and a clinical score calculated using the following parameters: regurgitation, vomiting, irritability, nocturnal weeping, meteorism, respiratory complaints. The total score was evaluated at diagnosis and during the follow-up (1st, 2nd, 4th and 8th week).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0391-5387 UR - https://www.unboundmedicine.com/medline/citation/8321715/[Cisapride_efficacy_in_gastroesophageal_reflux_in_children]_ L2 - http://www.diseaseinfosearch.org/result/2996 DB - PRIME DP - Unbound Medicine ER -