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Plasma lipids and VLDL composition in male non-insulin dependent diabetic patients: relation with HbA1c levels.
Res Commun Chem Pathol Pharmacol. 1993 May; 80(2):225-33.RC

Abstract

In this study, plasma lipids and VLDL composition were measured in 22 middle aged male patients with non-insulin dependent diabetes and compared with 15 non-diabetic controls. Data for the diabetics were differentiated on the basis of hemoglobin A1c levels of less than or greater than 7%. Compositional abnormalities of VLDL were more frequent in the diabetic patients with HbA1c of > 7%. VLDL-cholesterol, triglycerides and phospholipids were elevated in all diabetics whereas VLDL-Apo B was increased only in diabetics with HbA1c > 7%. Apo CII and Apo CIII levels and also apo CII/apo CIII ratio were also reduced with HbA1c levels of more than 7%. Increases in the apo E and apo E/apo C ratio were also seen in the more hyperglycemic diabetics with HbA1c levels of > 7%. In contrast apo CII and apo CIII levels and also apo CII/apo CIII ratio remained unaltered in diabetic patients with less than 7% HbA1c levels. In these patients increases in the apo E levels were found while the apo E/apo C ratio remained unaltered.

Authors+Show Affiliations

Instituto de Nutrición y Bromatología, (Centro Mixto UCM-CSIC), Universidad Complutens, Madrid, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8321922

Citation

Cuesta, C, et al. "Plasma Lipids and VLDL Composition in Male Non-insulin Dependent Diabetic Patients: Relation With HbA1c Levels." Research Communications in Chemical Pathology and Pharmacology, vol. 80, no. 2, 1993, pp. 225-33.
Cuesta C, Ródenas S, Sánchez-Cabezudo M. Plasma lipids and VLDL composition in male non-insulin dependent diabetic patients: relation with HbA1c levels. Res Commun Chem Pathol Pharmacol. 1993;80(2):225-33.
Cuesta, C., Ródenas, S., & Sánchez-Cabezudo, M. (1993). Plasma lipids and VLDL composition in male non-insulin dependent diabetic patients: relation with HbA1c levels. Research Communications in Chemical Pathology and Pharmacology, 80(2), 225-33.
Cuesta C, Ródenas S, Sánchez-Cabezudo M. Plasma Lipids and VLDL Composition in Male Non-insulin Dependent Diabetic Patients: Relation With HbA1c Levels. Res Commun Chem Pathol Pharmacol. 1993;80(2):225-33. PubMed PMID: 8321922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma lipids and VLDL composition in male non-insulin dependent diabetic patients: relation with HbA1c levels. AU - Cuesta,C, AU - Ródenas,S, AU - Sánchez-Cabezudo,M, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 225 EP - 33 JF - Research communications in chemical pathology and pharmacology JO - Res Commun Chem Pathol Pharmacol VL - 80 IS - 2 N2 - In this study, plasma lipids and VLDL composition were measured in 22 middle aged male patients with non-insulin dependent diabetes and compared with 15 non-diabetic controls. Data for the diabetics were differentiated on the basis of hemoglobin A1c levels of less than or greater than 7%. Compositional abnormalities of VLDL were more frequent in the diabetic patients with HbA1c of > 7%. VLDL-cholesterol, triglycerides and phospholipids were elevated in all diabetics whereas VLDL-Apo B was increased only in diabetics with HbA1c > 7%. Apo CII and Apo CIII levels and also apo CII/apo CIII ratio were also reduced with HbA1c levels of more than 7%. Increases in the apo E and apo E/apo C ratio were also seen in the more hyperglycemic diabetics with HbA1c levels of > 7%. In contrast apo CII and apo CIII levels and also apo CII/apo CIII ratio remained unaltered in diabetic patients with less than 7% HbA1c levels. In these patients increases in the apo E levels were found while the apo E/apo C ratio remained unaltered. SN - 0034-5164 UR - https://www.unboundmedicine.com/medline/citation/8321922/Plasma_lipids_and_VLDL_composition_in_male_non_insulin_dependent_diabetic_patients:_relation_with_HbA1c_levels_ L2 - https://medlineplus.gov/a1c.html DB - PRIME DP - Unbound Medicine ER -