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[Effect of verapamil on urinary calcium and oxalate excretion in renal stone formers].
Hinyokika Kiyo. 1993 May; 39(5):425-31.HK

Abstract

The effect of the calcium antagonist verapamil on urinary calcium and oxalate excretion was examined and compared with that of trichlormethiazide to evaluate whether verapamil is useful in the prevention of calcium oxalate renal stones. Twenty-four-hour urine of 16 renal stone formers was measured at the outpatient clinic before and after administration of 120 mg/day verapamil for a mean duration of 2.7 months (range, 2 weeks to 6 months). The 24-hour urine was analyzed for creatinine, calcium, oxalic acid, magnesium and citric acid and the results compared with those in 20 renal stone formers who were administered trichlormethiazide. Verapamil was found to significantly reduce the urinary oxalate excretion of the 5 hyperoxaluric (> or = 50 mg/day) patients but no significant effect on urinary calcium, magnesium or citric acid was observed. Conversely, trichlormethiazide significantly decreased urinary calcium excretion in the hypercalciuric (> or = 250 mg/day) patients. Calcium oxalate risk index of hypercalciuric and hyperoxaluric patients was significantly reduced after the administration of verapamil. These findings suggest that verapamil is effective in reducing urinary oxalate excretion in the hyperoxaluric patients.

Authors+Show Affiliations

Department of Urology, Kaizuka Municipal Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

8322624

Citation

Iguchi, M, et al. "[Effect of Verapamil On Urinary Calcium and Oxalate Excretion in Renal Stone Formers]." Hinyokika Kiyo. Acta Urologica Japonica, vol. 39, no. 5, 1993, pp. 425-31.
Iguchi M, Ikegami M, Kiwamoto H, et al. [Effect of verapamil on urinary calcium and oxalate excretion in renal stone formers]. Hinyokika Kiyo. 1993;39(5):425-31.
Iguchi, M., Ikegami, M., Kiwamoto, H., Umekawa, T., Ishikawa, Y., Kohri, K., & Kurita, T. (1993). [Effect of verapamil on urinary calcium and oxalate excretion in renal stone formers]. Hinyokika Kiyo. Acta Urologica Japonica, 39(5), 425-31.
Iguchi M, et al. [Effect of Verapamil On Urinary Calcium and Oxalate Excretion in Renal Stone Formers]. Hinyokika Kiyo. 1993;39(5):425-31. PubMed PMID: 8322624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of verapamil on urinary calcium and oxalate excretion in renal stone formers]. AU - Iguchi,M, AU - Ikegami,M, AU - Kiwamoto,H, AU - Umekawa,T, AU - Ishikawa,Y, AU - Kohri,K, AU - Kurita,T, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 425 EP - 31 JF - Hinyokika kiyo. Acta urologica Japonica JO - Hinyokika Kiyo VL - 39 IS - 5 N2 - The effect of the calcium antagonist verapamil on urinary calcium and oxalate excretion was examined and compared with that of trichlormethiazide to evaluate whether verapamil is useful in the prevention of calcium oxalate renal stones. Twenty-four-hour urine of 16 renal stone formers was measured at the outpatient clinic before and after administration of 120 mg/day verapamil for a mean duration of 2.7 months (range, 2 weeks to 6 months). The 24-hour urine was analyzed for creatinine, calcium, oxalic acid, magnesium and citric acid and the results compared with those in 20 renal stone formers who were administered trichlormethiazide. Verapamil was found to significantly reduce the urinary oxalate excretion of the 5 hyperoxaluric (> or = 50 mg/day) patients but no significant effect on urinary calcium, magnesium or citric acid was observed. Conversely, trichlormethiazide significantly decreased urinary calcium excretion in the hypercalciuric (> or = 250 mg/day) patients. Calcium oxalate risk index of hypercalciuric and hyperoxaluric patients was significantly reduced after the administration of verapamil. These findings suggest that verapamil is effective in reducing urinary oxalate excretion in the hyperoxaluric patients. SN - 0018-1994 UR - https://www.unboundmedicine.com/medline/citation/8322624/[Effect_of_verapamil_on_urinary_calcium_and_oxalate_excretion_in_renal_stone_formers]_ L2 - https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/117847 DB - PRIME DP - Unbound Medicine ER -