Tags

Type your tag names separated by a space and hit enter

Lung fibrosis in hypersensitivity pneumonitis. Association with CD4+ but not CD8+ cell dominant alveolitis and insidious onset.
Chest. 1993 Jul; 104(1):38-43.Chest

Abstract

Seventeen cases of hypersensitivity pneumonitis (HP) at a symptomatic phase were categorized into two groups based on computed tomographic (CT) findings and histologic features of transbronchial lung biopsy specimens, HP accompanied by lung fibrosis (fibrosis group), and HP unaccompanied by lung fibrosis (nonfibrosis group). The fibrosis group comprised bird fancier's lung and HP of unknown etiology, whereas the nonfibrosis group mainly comprised summer-type HP. Comparison of results of pulmonary function tests between these two groups confirmed a restrictive impairment in the fibrosis group. Analyses of cellular components of bronchoalveolar lavage (BAL) fluids revealed lymphocytes, especially CD8+ T lymphocytes, were significantly increased in the nonfibrosis group in comparison with the fibrosis group, whereas CD4+ T cells were increased to the same level in the both groups. Analyses of the onset of disease showed that acute onset was observed mainly in nonfibrosis group and strongly correlated with increased CD8+ T lymphocytes in BAL fluids, while insidious onset was related to lung fibrosis and relatively increased CD4+ T lymphocytes in BAL fluids. These findings raise the possibility that highly elevated CD8+ T cells might have a protective effect on pulmonary fibrosis or that relatively increased CD4+ T cells might play an important role in the pathogenesis of pulmonary fibrosis of HP at the chronic phase.

Authors+Show Affiliations

Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8325114

Citation

Murayama, J, et al. "Lung Fibrosis in Hypersensitivity Pneumonitis. Association With CD4+ but Not CD8+ Cell Dominant Alveolitis and Insidious Onset." Chest, vol. 104, no. 1, 1993, pp. 38-43.
Murayama J, Yoshizawa Y, Ohtsuka M, et al. Lung fibrosis in hypersensitivity pneumonitis. Association with CD4+ but not CD8+ cell dominant alveolitis and insidious onset. Chest. 1993;104(1):38-43.
Murayama, J., Yoshizawa, Y., Ohtsuka, M., & Hasegawa, S. (1993). Lung fibrosis in hypersensitivity pneumonitis. Association with CD4+ but not CD8+ cell dominant alveolitis and insidious onset. Chest, 104(1), 38-43.
Murayama J, et al. Lung Fibrosis in Hypersensitivity Pneumonitis. Association With CD4+ but Not CD8+ Cell Dominant Alveolitis and Insidious Onset. Chest. 1993;104(1):38-43. PubMed PMID: 8325114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lung fibrosis in hypersensitivity pneumonitis. Association with CD4+ but not CD8+ cell dominant alveolitis and insidious onset. AU - Murayama,J, AU - Yoshizawa,Y, AU - Ohtsuka,M, AU - Hasegawa,S, PY - 1993/7/1/pubmed PY - 1993/7/1/medline PY - 1993/7/1/entrez SP - 38 EP - 43 JF - Chest JO - Chest VL - 104 IS - 1 N2 - Seventeen cases of hypersensitivity pneumonitis (HP) at a symptomatic phase were categorized into two groups based on computed tomographic (CT) findings and histologic features of transbronchial lung biopsy specimens, HP accompanied by lung fibrosis (fibrosis group), and HP unaccompanied by lung fibrosis (nonfibrosis group). The fibrosis group comprised bird fancier's lung and HP of unknown etiology, whereas the nonfibrosis group mainly comprised summer-type HP. Comparison of results of pulmonary function tests between these two groups confirmed a restrictive impairment in the fibrosis group. Analyses of cellular components of bronchoalveolar lavage (BAL) fluids revealed lymphocytes, especially CD8+ T lymphocytes, were significantly increased in the nonfibrosis group in comparison with the fibrosis group, whereas CD4+ T cells were increased to the same level in the both groups. Analyses of the onset of disease showed that acute onset was observed mainly in nonfibrosis group and strongly correlated with increased CD8+ T lymphocytes in BAL fluids, while insidious onset was related to lung fibrosis and relatively increased CD4+ T lymphocytes in BAL fluids. These findings raise the possibility that highly elevated CD8+ T cells might have a protective effect on pulmonary fibrosis or that relatively increased CD4+ T cells might play an important role in the pathogenesis of pulmonary fibrosis of HP at the chronic phase. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/8325114/Lung_fibrosis_in_hypersensitivity_pneumonitis__Association_with_CD4+_but_not_CD8+_cell_dominant_alveolitis_and_insidious_onset_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(16)47469-6 DB - PRIME DP - Unbound Medicine ER -