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Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients.
Int J Lepr Other Mycobact Dis. 1993 Mar; 61(1):29-34.IJ

Abstract

IgG antibodies against antigens 85A and 85B from Mycobacterium bovis BCG, IgM antibodies against phenolic glycolipid-I (PGL-I) and circulating PGL-I antigen were measured in the serum of 11 patients with lepromatous leprosy receiving multidrug therapy (MDT). Before treatment, 6 patients were reactive to antigen 85A, 10 patients to antigen 85B, and 11 patients to PGL-I; circulating PGL-I was detected in the sera of all of them. After 2 years of MDT PGL-I antigen could no longer be detected in all of the patients, except for two who were not compliant with treatment. IgG antibodies directed against the 85A and 85B antigens and IgM antibodies against the PGL-I antigen also decreased significantly during treatment but more slowly. The determination of circulating PGL-I antigen remains the most appropriate tool for monitoring lepromatous leprosy under MDT.

Authors+Show Affiliations

Drowart A
Chest Department, Hôpital Erasme, Brussels, Belgium.
Chanteau S
No affiliation info available
Huygen K
No affiliation info available
De Cock M
No affiliation info available
Cartel JL
No affiliation info available
De Bruyn J
No affiliation info available
Launois P
No affiliation info available
Yernault JC
No affiliation info available
Van Vooren JP
No affiliation info available

MeSH

Antibodies, BacterialAntigens, BacterialClofazimineDapsoneDrug Therapy, CombinationGlycolipidsHumansImmunoglobulin GImmunoglobulin MIsoelectric FocusingLeprostatic AgentsLeprosy, LepromatousMycobacterium bovisMycobacterium lepraePatient ComplianceProthionamideRifampin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8326178

Citation

Drowart, A, et al. "Effects of Chemotherapy On Antibody Levels Directed Against PGL-I and 85A and 85B Protein Antigens in Lepromatous Patients." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 61, no. 1, 1993, pp. 29-34.
Drowart A, Chanteau S, Huygen K, et al. Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients. Int J Lepr Other Mycobact Dis. 1993;61(1):29-34.
Drowart, A., Chanteau, S., Huygen, K., De Cock, M., Cartel, J. L., De Bruyn, J., Launois, P., Yernault, J. C., & Van Vooren, J. P. (1993). Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 61(1), 29-34.
Drowart A, et al. Effects of Chemotherapy On Antibody Levels Directed Against PGL-I and 85A and 85B Protein Antigens in Lepromatous Patients. Int J Lepr Other Mycobact Dis. 1993;61(1):29-34. PubMed PMID: 8326178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients. AU - Drowart,A, AU - Chanteau,S, AU - Huygen,K, AU - De Cock,M, AU - Cartel,J L, AU - De Bruyn,J, AU - Launois,P, AU - Yernault,J C, AU - Van Vooren,J P, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 29 EP - 34 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 61 IS - 1 N2 - IgG antibodies against antigens 85A and 85B from Mycobacterium bovis BCG, IgM antibodies against phenolic glycolipid-I (PGL-I) and circulating PGL-I antigen were measured in the serum of 11 patients with lepromatous leprosy receiving multidrug therapy (MDT). Before treatment, 6 patients were reactive to antigen 85A, 10 patients to antigen 85B, and 11 patients to PGL-I; circulating PGL-I was detected in the sera of all of them. After 2 years of MDT PGL-I antigen could no longer be detected in all of the patients, except for two who were not compliant with treatment. IgG antibodies directed against the 85A and 85B antigens and IgM antibodies against the PGL-I antigen also decreased significantly during treatment but more slowly. The determination of circulating PGL-I antigen remains the most appropriate tool for monitoring lepromatous leprosy under MDT. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/8326178/Effects_of_chemotherapy_on_antibody_levels_directed_against_PGL_I_and_85A_and_85B_protein_antigens_in_lepromatous_patients_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:8326178 DB - PRIME DP - Unbound Medicine ER -