Miyajima, Y, et al. "Wernicke's Encephalopathy in a Child With Acute Lymphoblastic Leukemia." The American Journal of Pediatric Hematology/oncology, vol. 15, no. 3, 1993, pp. 331-4.
Miyajima Y, Fukuda M, Kojima S, et al. Wernicke's encephalopathy in a child with acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol. 1993;15(3):331-4.
Miyajima, Y., Fukuda, M., Kojima, S., Matsuyama, T., Shylaja, N., & Aso, K. (1993). Wernicke's encephalopathy in a child with acute lymphoblastic leukemia. The American Journal of Pediatric Hematology/oncology, 15(3), 331-4.
Miyajima Y, et al. Wernicke's Encephalopathy in a Child With Acute Lymphoblastic Leukemia. Am J Pediatr Hematol Oncol. 1993;15(3):331-4. PubMed PMID: 8328648.
TY - JOUR
T1 - Wernicke's encephalopathy in a child with acute lymphoblastic leukemia.
AU - Miyajima,Y,
AU - Fukuda,M,
AU - Kojima,S,
AU - Matsuyama,T,
AU - Shylaja,N,
AU - Aso,K,
PY - 1993/8/1/pubmed
PY - 1993/8/1/medline
PY - 1993/8/1/entrez
SP - 331
EP - 4
JF - The American journal of pediatric hematology/oncology
JO - Am J Pediatr Hematol Oncol
VL - 15
IS - 3
N2 - PURPOSE: We describe the case of a 9-year-old boy who developed Wernicke's encephalopathy while receiving chemotherapy for acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: After suffering anorexia for 4 weeks following chemotherapy, he exhibited nystagmus and ataxia. Symptoms rapidly worsened following an increased glucose load, and included a depressed consciousness, irregular respiration, and ophthalmoplegia. The serum thiamine level was 9 ng/ml (normal: 20-50). Cranial computed tomography (CT) revealed a low density area bilaterally at the neostriatum. Thiamine 100 mg/day was administered intravenously. RESULTS: The patient's neurological signs improved dramatically. However, he subsequently developed pancytopenia and died of pneumonia. CONCLUSION: The possibility of Wernicke's encephalopathy should be considered in children who are receiving chemotherapy for malignant disease when a persistent loss of appetite is followed by such neurological symptoms as nystagmus and ataxia.
SN - 0192-8562
UR - https://www.unboundmedicine.com/medline/citation/8328648/Wernicke's_encephalopathy_in_a_child_with_acute_lymphoblastic_leukemia_
L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8328648.ui
DB - PRIME
DP - Unbound Medicine