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Lipoprotein compositional abnormalities in type 1 (insulin-dependent) diabetic patients.
Acta Diabetol 1993; 30(1):11-6AD

Abstract

Patients with type 1 (insulin-dependent) diabetes mellitus in good metabolic control usually have normal plasma lipid levels yet they have an increased incidence of vascular complications. Abnormalities in the distribution and composition of lipoprotein subfractions might in part be responsible for the macroangiopathy seen in type 1 diabetes mellitus. The plasma lipids, lipoproteins and apolipoproteins were studied in 9 type 1 diabetic patients during conventional insulin therapy and in 14 healthy controls. Plasma lipoproteins were analysed by ultracentrifugation in a zonal rotor to evaluate their concentrations and flotation properties and for compositional analysis. In diabetic patients the mean glycosylated haemoglobin (HbA1c) was 9.44 +/- 1.02% and the plasma lipid concentrations were not significantly different from healthy controls. The very low density lipoprotein (VLDL) subclass cholesterol concentrations were no different in diabetic patients and control subjects, but the VLDL cholesterol/triglyceride ratio was significantly lower in diabetic patients than in control subjects (0.43 +/- 0.05 vs 0.85 +/- 0.14; p < 0.05). The flotation rate LDL2, the major component of low density lipoprotein (LDL) was lower in the diabetic patients compared with the control subjects. The cholesterol concentrations of intermediate density lipoprotein and LDL3, the minor component of LDL, were significantly higher (0.17 +/- 0.03 and 0.83 +/- 0.14 mmol/l respectively) in diabetic patients than in control subjects (0.05 +/- 0.02 and 0.24 +/- 0.08 mmol/l). The flotation properties and cholesterol concentrations of the high density lipoprotein (HDL) subclass, and the protein-lipid composition of LDL2, HDL2 and HDL3, were no different in diabetic patients and control subjects.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Internal Medicine, University of Padua, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8329725

Citation

Manzato, E, et al. "Lipoprotein Compositional Abnormalities in Type 1 (insulin-dependent) Diabetic Patients." Acta Diabetologica, vol. 30, no. 1, 1993, pp. 11-6.
Manzato E, Zambon A, Zambon S, et al. Lipoprotein compositional abnormalities in type 1 (insulin-dependent) diabetic patients. Acta Diabetol. 1993;30(1):11-6.
Manzato, E., Zambon, A., Zambon, S., Nosadini, R., Doria, A., Marin, R., & Crepaldi, G. (1993). Lipoprotein compositional abnormalities in type 1 (insulin-dependent) diabetic patients. Acta Diabetologica, 30(1), pp. 11-6.
Manzato E, et al. Lipoprotein Compositional Abnormalities in Type 1 (insulin-dependent) Diabetic Patients. Acta Diabetol. 1993;30(1):11-6. PubMed PMID: 8329725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoprotein compositional abnormalities in type 1 (insulin-dependent) diabetic patients. AU - Manzato,E, AU - Zambon,A, AU - Zambon,S, AU - Nosadini,R, AU - Doria,A, AU - Marin,R, AU - Crepaldi,G, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 11 EP - 6 JF - Acta diabetologica JO - Acta Diabetol VL - 30 IS - 1 N2 - Patients with type 1 (insulin-dependent) diabetes mellitus in good metabolic control usually have normal plasma lipid levels yet they have an increased incidence of vascular complications. Abnormalities in the distribution and composition of lipoprotein subfractions might in part be responsible for the macroangiopathy seen in type 1 diabetes mellitus. The plasma lipids, lipoproteins and apolipoproteins were studied in 9 type 1 diabetic patients during conventional insulin therapy and in 14 healthy controls. Plasma lipoproteins were analysed by ultracentrifugation in a zonal rotor to evaluate their concentrations and flotation properties and for compositional analysis. In diabetic patients the mean glycosylated haemoglobin (HbA1c) was 9.44 +/- 1.02% and the plasma lipid concentrations were not significantly different from healthy controls. The very low density lipoprotein (VLDL) subclass cholesterol concentrations were no different in diabetic patients and control subjects, but the VLDL cholesterol/triglyceride ratio was significantly lower in diabetic patients than in control subjects (0.43 +/- 0.05 vs 0.85 +/- 0.14; p < 0.05). The flotation rate LDL2, the major component of low density lipoprotein (LDL) was lower in the diabetic patients compared with the control subjects. The cholesterol concentrations of intermediate density lipoprotein and LDL3, the minor component of LDL, were significantly higher (0.17 +/- 0.03 and 0.83 +/- 0.14 mmol/l respectively) in diabetic patients than in control subjects (0.05 +/- 0.02 and 0.24 +/- 0.08 mmol/l). The flotation properties and cholesterol concentrations of the high density lipoprotein (HDL) subclass, and the protein-lipid composition of LDL2, HDL2 and HDL3, were no different in diabetic patients and control subjects.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0940-5429 UR - https://www.unboundmedicine.com/medline/citation/8329725/Lipoprotein_compositional_abnormalities_in_type_1__insulin_dependent__diabetic_patients_ L2 - https://medlineplus.gov/diabetestype1.html DB - PRIME DP - Unbound Medicine ER -