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Fragrance compounds and essential oils with sedative effects upon inhalation.
J Pharm Sci. 1993 Jun; 82(6):660-4.JP

Abstract

Fragrance compounds and essential oils with sedative effects influence the motility of mice in inhalation studies under standardized conditions. A significant drop in the motility of mice was registered following exposure to these fragrances. The same results were achieved when the mice were artificially induced into overagitation by intraperitoneal application of caffeine and subsequently subjected to inhalation of fragrance compounds and essential oils. These results proved the sedative effects of these fragrants via inhalative exposure in low concentrations. Blood samples were taken from the mice after a 1-h inhalation period. Chromatographic and spectroscopic methods were used to detect and characterize the actual effective compounds after solid-phase extraction. Serum concentrations of 42 different substances, including fragrance compounds, were found in low ranges (ng/mL serum). The results contribute to the correct interpretation of the term aromatherapy (i.e., a stimulating or sedative effect on the behaviour of individuals only upon inhalation of fragrance compounds).

Authors+Show Affiliations

Institute of Pharmaceutical Chemistry, University of Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8331544

Citation

Buchbauer, G, et al. "Fragrance Compounds and Essential Oils With Sedative Effects Upon Inhalation." Journal of Pharmaceutical Sciences, vol. 82, no. 6, 1993, pp. 660-4.
Buchbauer G, Jirovetz L, Jäger W, et al. Fragrance compounds and essential oils with sedative effects upon inhalation. J Pharm Sci. 1993;82(6):660-4.
Buchbauer, G., Jirovetz, L., Jäger, W., Plank, C., & Dietrich, H. (1993). Fragrance compounds and essential oils with sedative effects upon inhalation. Journal of Pharmaceutical Sciences, 82(6), 660-4.
Buchbauer G, et al. Fragrance Compounds and Essential Oils With Sedative Effects Upon Inhalation. J Pharm Sci. 1993;82(6):660-4. PubMed PMID: 8331544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fragrance compounds and essential oils with sedative effects upon inhalation. AU - Buchbauer,G, AU - Jirovetz,L, AU - Jäger,W, AU - Plank,C, AU - Dietrich,H, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 660 EP - 4 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 82 IS - 6 N2 - Fragrance compounds and essential oils with sedative effects influence the motility of mice in inhalation studies under standardized conditions. A significant drop in the motility of mice was registered following exposure to these fragrances. The same results were achieved when the mice were artificially induced into overagitation by intraperitoneal application of caffeine and subsequently subjected to inhalation of fragrance compounds and essential oils. These results proved the sedative effects of these fragrants via inhalative exposure in low concentrations. Blood samples were taken from the mice after a 1-h inhalation period. Chromatographic and spectroscopic methods were used to detect and characterize the actual effective compounds after solid-phase extraction. Serum concentrations of 42 different substances, including fragrance compounds, were found in low ranges (ng/mL serum). The results contribute to the correct interpretation of the term aromatherapy (i.e., a stimulating or sedative effect on the behaviour of individuals only upon inhalation of fragrance compounds). SN - 0022-3549 UR - https://www.unboundmedicine.com/medline/citation/8331544/Fragrance_compounds_and_essential_oils_with_sedative_effects_upon_inhalation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(15)49151-8 DB - PRIME DP - Unbound Medicine ER -