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Disturbed galactose metabolism in elderly and diabetic humans is associated with cataract formation.

Abstract

Lactose consumption has been associated with a high incidence of cataract in northern Indian and southern Italian populations. Galactose absorbed after hydrolysis of lactose from milk in individuals with normal lactase activity is considered responsible. However, lactase-deficient subjects who often avoid drinking milk are able to digest lactose and absorb free galactose in fermented milk and yogurt. This study was conducted to evaluate the relationships between milk and yogurt consumption, galactose metabolism and cataract risk. Milk ingestion was dose-related with cataract risk in lactose digesters (particularly in diabetics) but not in lactose maldigesters. Conversely, yogurt intake had a protective dose-effect on cataract formation for the whole population. Maximal galactose concentrations after an oral galactose test increased exponentially with age. Red blood cell galactokinase activity was significantly lower in elderly subjects (> 60 y) than in young individuals (P < 0.05), and galactose-1-phosphate uridyl-transferase activity was significantly lower in institutionalized subjects and in home-living elderly with cataract than in healthy elderly subjects (P < 0.05). We conclude that the cataractogenic action of milk lactose is dependent on the disturbance of galactose metabolism in elderly subjects and that yogurt is not cataractogenic, although the mechanism of the protective effect of yogurt remains unknown.

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  • Authors+Show Affiliations

    ,

    Analytical Chemistry Laboratory, Institut National Agronomique, Paris, France.

    , , ,

    Source

    The Journal of nutrition 123:8 1993 Aug pg 1370-6

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Aging
    Animals
    Case-Control Studies
    Cataract
    Diabetes Complications
    Diabetes Mellitus
    Digestion
    Eating
    Erythrocytes
    Female
    Galactokinase
    Galactose
    Humans
    Lactose
    Lactose Intolerance
    Male
    Middle Aged
    Milk
    Odds Ratio
    Retrospective Studies
    Risk Factors
    UTP-Hexose-1-Phosphate Uridylyltransferase
    Yogurt

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8336207

    Citation

    Birlouez-Aragon, I, et al. "Disturbed Galactose Metabolism in Elderly and Diabetic Humans Is Associated With Cataract Formation." The Journal of Nutrition, vol. 123, no. 8, 1993, pp. 1370-6.
    Birlouez-Aragon I, Ravelontseheno L, Villate-Cathelineau B, et al. Disturbed galactose metabolism in elderly and diabetic humans is associated with cataract formation. J Nutr. 1993;123(8):1370-6.
    Birlouez-Aragon, I., Ravelontseheno, L., Villate-Cathelineau, B., Cathelineau, G., & Abitbol, G. (1993). Disturbed galactose metabolism in elderly and diabetic humans is associated with cataract formation. The Journal of Nutrition, 123(8), pp. 1370-6.
    Birlouez-Aragon I, et al. Disturbed Galactose Metabolism in Elderly and Diabetic Humans Is Associated With Cataract Formation. J Nutr. 1993;123(8):1370-6. PubMed PMID: 8336207.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Disturbed galactose metabolism in elderly and diabetic humans is associated with cataract formation. AU - Birlouez-Aragon,I, AU - Ravelontseheno,L, AU - Villate-Cathelineau,B, AU - Cathelineau,G, AU - Abitbol,G, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 1370 EP - 6 JF - The Journal of nutrition JO - J. Nutr. VL - 123 IS - 8 N2 - Lactose consumption has been associated with a high incidence of cataract in northern Indian and southern Italian populations. Galactose absorbed after hydrolysis of lactose from milk in individuals with normal lactase activity is considered responsible. However, lactase-deficient subjects who often avoid drinking milk are able to digest lactose and absorb free galactose in fermented milk and yogurt. This study was conducted to evaluate the relationships between milk and yogurt consumption, galactose metabolism and cataract risk. Milk ingestion was dose-related with cataract risk in lactose digesters (particularly in diabetics) but not in lactose maldigesters. Conversely, yogurt intake had a protective dose-effect on cataract formation for the whole population. Maximal galactose concentrations after an oral galactose test increased exponentially with age. Red blood cell galactokinase activity was significantly lower in elderly subjects (> 60 y) than in young individuals (P < 0.05), and galactose-1-phosphate uridyl-transferase activity was significantly lower in institutionalized subjects and in home-living elderly with cataract than in healthy elderly subjects (P < 0.05). We conclude that the cataractogenic action of milk lactose is dependent on the disturbance of galactose metabolism in elderly subjects and that yogurt is not cataractogenic, although the mechanism of the protective effect of yogurt remains unknown. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/8336207/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/123.8.1370 DB - PRIME DP - Unbound Medicine ER -