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Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer.
Cancer Res. 1993 Aug 15; 53(16):3795-9.CR

Abstract

The mutation patterns of the p53 tumor suppressor gene have been shown to reflect the specific carcinogen(s) involved, or the epidemiological background in some cancers. To elucidate the impact of cigarette smoking or bilharzial infection on the p53 gene mutation pattern, 61 cases of urothelial cancer from Japan and 7 cases of bladder cancer with schistosomiasis from Egypt were examined for mutations of the p53 gene. In total, p53 gene mutations were detected in 20 Japanese cases (33%) and 6 Egyptian cases (86%). Although the incidence of p53 gene mutation was not significantly influenced by habitual smoking, a different mutation pattern was observed as follows: 4 of 10 mutations in smokers in Japan were A:T to G:C transitions, whereas such mutations were not detected in any of 10 mutations in nonsmokers, or in any of 6 mutations associated with schistosomiasis. Although no specific mutation pattern was detected for the squamous cell carcinomas with schistosomiasis, all 8 base substitutions observed in tumors with squamous cell carcinomas occurred at G:C sites, whereas base substitutions at A:T sites were observed in 33% (6 of 18) of mutations in transitional cell carcinomas. Our results suggest that cigarette smoking may have a significant impact on the mutations of the p53 gene in urothelial cancers. Furthermore, the distinct spectrum of the p53 gene mutation found in tumors with squamous cell carcinomas may reflect their unique etiological backgrounds.

Authors+Show Affiliations

Department of Urology, Faculty of Medicine, Kyoto University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8339293

Citation

Habuchi, T, et al. "Influence of Cigarette Smoking and Schistosomiasis On P53 Gene Mutation in Urothelial Cancer." Cancer Research, vol. 53, no. 16, 1993, pp. 3795-9.
Habuchi T, Takahashi R, Yamada H, et al. Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer. Cancer Res. 1993;53(16):3795-9.
Habuchi, T., Takahashi, R., Yamada, H., Ogawa, O., Kakehi, Y., Ogura, K., Hamazaki, S., Toguchida, J., Ishizaki, K., & Fujita, J. (1993). Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer. Cancer Research, 53(16), 3795-9.
Habuchi T, et al. Influence of Cigarette Smoking and Schistosomiasis On P53 Gene Mutation in Urothelial Cancer. Cancer Res. 1993 Aug 15;53(16):3795-9. PubMed PMID: 8339293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer. A1 - Habuchi,T, AU - Takahashi,R, AU - Yamada,H, AU - Ogawa,O, AU - Kakehi,Y, AU - Ogura,K, AU - Hamazaki,S, AU - Toguchida,J, AU - Ishizaki,K, AU - Fujita,J, PY - 1993/8/15/pubmed PY - 1993/8/15/medline PY - 1993/8/15/entrez SP - 3795 EP - 9 JF - Cancer research JO - Cancer Res. VL - 53 IS - 16 N2 - The mutation patterns of the p53 tumor suppressor gene have been shown to reflect the specific carcinogen(s) involved, or the epidemiological background in some cancers. To elucidate the impact of cigarette smoking or bilharzial infection on the p53 gene mutation pattern, 61 cases of urothelial cancer from Japan and 7 cases of bladder cancer with schistosomiasis from Egypt were examined for mutations of the p53 gene. In total, p53 gene mutations were detected in 20 Japanese cases (33%) and 6 Egyptian cases (86%). Although the incidence of p53 gene mutation was not significantly influenced by habitual smoking, a different mutation pattern was observed as follows: 4 of 10 mutations in smokers in Japan were A:T to G:C transitions, whereas such mutations were not detected in any of 10 mutations in nonsmokers, or in any of 6 mutations associated with schistosomiasis. Although no specific mutation pattern was detected for the squamous cell carcinomas with schistosomiasis, all 8 base substitutions observed in tumors with squamous cell carcinomas occurred at G:C sites, whereas base substitutions at A:T sites were observed in 33% (6 of 18) of mutations in transitional cell carcinomas. Our results suggest that cigarette smoking may have a significant impact on the mutations of the p53 gene in urothelial cancers. Furthermore, the distinct spectrum of the p53 gene mutation found in tumors with squamous cell carcinomas may reflect their unique etiological backgrounds. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/8339293/Influence_of_cigarette_smoking_and_schistosomiasis_on_p53_gene_mutation_in_urothelial_cancer_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8339293 DB - PRIME DP - Unbound Medicine ER -