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Effect of hydrochlorothiazide therapy on the crystallization of calcium oxalate in urine.
Metabolism. 1977 Feb; 26(2):201-5.M

Abstract

The effect of hydrochlorothiazide on the formation of renal stones was evaluated by quantitative assessment of the propensity of urine to undergo crystallization of calcium oxalate. In seven patients with calcium urolithiasis (three with absorptive hypercalciuria, one with renal hypercalciuria, and three with normocalciuric nephrolithiasis), the urinary activity product ratio and formation product ratio of calcium oxalate were measured both on and off therapy with hydrochlorothiazide (50 mg orally twice a day). The activity product ratio (state of saturation with respect to calcium oxalate) decreased in the majority of cases, primarily as a result of the fall in urinary calcium. The formation product ratio (limit of metastability) increased in all cases; the cause of the increase was not readily apparent. Both changes reduced the propensity of urine to undergo crystallization of calcium oxalate, and therefore may account for the clinical improvement reported during thiazide therapy in nephrolithiasis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

834153

Citation

Woelfel, A, et al. "Effect of Hydrochlorothiazide Therapy On the Crystallization of Calcium Oxalate in Urine." Metabolism: Clinical and Experimental, vol. 26, no. 2, 1977, pp. 201-5.
Woelfel A, Kaplan RA, Pak CY. Effect of hydrochlorothiazide therapy on the crystallization of calcium oxalate in urine. Metab Clin Exp. 1977;26(2):201-5.
Woelfel, A., Kaplan, R. A., & Pak, C. Y. (1977). Effect of hydrochlorothiazide therapy on the crystallization of calcium oxalate in urine. Metabolism: Clinical and Experimental, 26(2), 201-5.
Woelfel A, Kaplan RA, Pak CY. Effect of Hydrochlorothiazide Therapy On the Crystallization of Calcium Oxalate in Urine. Metab Clin Exp. 1977;26(2):201-5. PubMed PMID: 834153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of hydrochlorothiazide therapy on the crystallization of calcium oxalate in urine. AU - Woelfel,A, AU - Kaplan,R A, AU - Pak,C Y, PY - 1977/2/1/pubmed PY - 1977/2/1/medline PY - 1977/2/1/entrez SP - 201 EP - 5 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 26 IS - 2 N2 - The effect of hydrochlorothiazide on the formation of renal stones was evaluated by quantitative assessment of the propensity of urine to undergo crystallization of calcium oxalate. In seven patients with calcium urolithiasis (three with absorptive hypercalciuria, one with renal hypercalciuria, and three with normocalciuric nephrolithiasis), the urinary activity product ratio and formation product ratio of calcium oxalate were measured both on and off therapy with hydrochlorothiazide (50 mg orally twice a day). The activity product ratio (state of saturation with respect to calcium oxalate) decreased in the majority of cases, primarily as a result of the fall in urinary calcium. The formation product ratio (limit of metastability) increased in all cases; the cause of the increase was not readily apparent. Both changes reduced the propensity of urine to undergo crystallization of calcium oxalate, and therefore may account for the clinical improvement reported during thiazide therapy in nephrolithiasis. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/834153/Effect_of_hydrochlorothiazide_therapy_on_the_crystallization_of_calcium_oxalate_in_urine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(77)90056-7 DB - PRIME DP - Unbound Medicine ER -