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Use of alprazolam for relief of tinnitus. A double-blind study.
Arch Otolaryngol Head Neck Surg. 1993 Aug; 119(8):842-5.AO

Abstract

OBJECTIVE

To systematically test the effectiveness of alprazolam as a pharmacological agent for patients with tinnitus.

DESIGN

Prospective, placebo-controlled, double-blind study.

PATIENTS

Forty adult patients with constant tinnitus who had experienced their tinnitus for a minimum of 1 year and who resided in the Portland, Ore, metropolitan area. Twenty patients were randomly assigned to the experimental group and 20 to the control group.

RESULTS

Seventeen of 20 patients in the experimental (alprazolam) group and 19 of the 20 in the placebo (lactose) group completed the study. Of the 17 patients receiving alprazolam, 13 (76%) had a reduction in the loudness of their tinnitus when measurements were made using a tinnitus synthesizer and a visual analog scale. Only one of the 19 who received the placebo showed any improvement in the loudness of their tinnitus. No changes were observed in the audiometric data or in tinnitus masking levels for either group. Individuals differed in the dosages required to achieve benefit from the alprazolam, and the side effects were minimal for this 12-week study.

CONCLUSIONS

Alprazolam is a drug that will provide therapeutic relief for some patients with tinnitus. Regulation of the prescribed dosage of alprazolam is important since individuals differ considerably in sensitivity to this medication.

Authors+Show Affiliations

Department of Otolaryngology, Oregon Health Sciences University, Portland.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8343245

Citation

Johnson, R M., et al. "Use of Alprazolam for Relief of Tinnitus. a Double-blind Study." Archives of Otolaryngology--head & Neck Surgery, vol. 119, no. 8, 1993, pp. 842-5.
Johnson RM, Brummett R, Schleuning A. Use of alprazolam for relief of tinnitus. A double-blind study. Arch Otolaryngol Head Neck Surg. 1993;119(8):842-5.
Johnson, R. M., Brummett, R., & Schleuning, A. (1993). Use of alprazolam for relief of tinnitus. A double-blind study. Archives of Otolaryngology--head & Neck Surgery, 119(8), 842-5.
Johnson RM, Brummett R, Schleuning A. Use of Alprazolam for Relief of Tinnitus. a Double-blind Study. Arch Otolaryngol Head Neck Surg. 1993;119(8):842-5. PubMed PMID: 8343245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of alprazolam for relief of tinnitus. A double-blind study. AU - Johnson,R M, AU - Brummett,R, AU - Schleuning,A, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 842 EP - 5 JF - Archives of otolaryngology--head & neck surgery JO - Arch Otolaryngol Head Neck Surg VL - 119 IS - 8 N2 - OBJECTIVE: To systematically test the effectiveness of alprazolam as a pharmacological agent for patients with tinnitus. DESIGN: Prospective, placebo-controlled, double-blind study. PATIENTS: Forty adult patients with constant tinnitus who had experienced their tinnitus for a minimum of 1 year and who resided in the Portland, Ore, metropolitan area. Twenty patients were randomly assigned to the experimental group and 20 to the control group. RESULTS: Seventeen of 20 patients in the experimental (alprazolam) group and 19 of the 20 in the placebo (lactose) group completed the study. Of the 17 patients receiving alprazolam, 13 (76%) had a reduction in the loudness of their tinnitus when measurements were made using a tinnitus synthesizer and a visual analog scale. Only one of the 19 who received the placebo showed any improvement in the loudness of their tinnitus. No changes were observed in the audiometric data or in tinnitus masking levels for either group. Individuals differed in the dosages required to achieve benefit from the alprazolam, and the side effects were minimal for this 12-week study. CONCLUSIONS: Alprazolam is a drug that will provide therapeutic relief for some patients with tinnitus. Regulation of the prescribed dosage of alprazolam is important since individuals differ considerably in sensitivity to this medication. SN - 0886-4470 UR - https://www.unboundmedicine.com/medline/citation/8343245/Use_of_alprazolam_for_relief_of_tinnitus__A_double_blind_study_ L2 - https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/vol/119/pg/842 DB - PRIME DP - Unbound Medicine ER -