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Distribution and activity of glutathione-S-transferase in normal human lenses and in cataractous human epithelia.
Curr Eye Res. 1993 May; 12(5):433-7.CE

Abstract

The distribution of glutathione-S-transferase (GST) activity was determined in frozen normal human lenses. The highest activity of GST was found in the peripheral and equatorial regions, whereas the lowest activity was found in the nucleus. Western blot showed that both mu and pi isoenzymes of GST were present in human lenses. This result is similar to that found in rat lenses. In addition, GST activity was analyzed in 50 lens epithelia which were obtained during cataract surgery. Twenty-seven lens epithelia showed no activity. Statistically significant association was found between cortical and mixed cortical--nuclear cataract and loss of GST activity. No association was found between pure nuclear cataract and loss of epithelial GST activity.

Authors+Show Affiliations

Jules Stein Eye Institute, UCLA School of Medicine 90024-7008.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8344067

Citation

Huang, Q L., et al. "Distribution and Activity of glutathione-S-transferase in Normal Human Lenses and in Cataractous Human Epithelia." Current Eye Research, vol. 12, no. 5, 1993, pp. 433-7.
Huang QL, Lou MF, Straatsma BR, et al. Distribution and activity of glutathione-S-transferase in normal human lenses and in cataractous human epithelia. Curr Eye Res. 1993;12(5):433-7.
Huang, Q. L., Lou, M. F., Straatsma, B. R., & Horwitz, J. (1993). Distribution and activity of glutathione-S-transferase in normal human lenses and in cataractous human epithelia. Current Eye Research, 12(5), 433-7.
Huang QL, et al. Distribution and Activity of glutathione-S-transferase in Normal Human Lenses and in Cataractous Human Epithelia. Curr Eye Res. 1993;12(5):433-7. PubMed PMID: 8344067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution and activity of glutathione-S-transferase in normal human lenses and in cataractous human epithelia. AU - Huang,Q L, AU - Lou,M F, AU - Straatsma,B R, AU - Horwitz,J, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 433 EP - 7 JF - Current eye research JO - Curr Eye Res VL - 12 IS - 5 N2 - The distribution of glutathione-S-transferase (GST) activity was determined in frozen normal human lenses. The highest activity of GST was found in the peripheral and equatorial regions, whereas the lowest activity was found in the nucleus. Western blot showed that both mu and pi isoenzymes of GST were present in human lenses. This result is similar to that found in rat lenses. In addition, GST activity was analyzed in 50 lens epithelia which were obtained during cataract surgery. Twenty-seven lens epithelia showed no activity. Statistically significant association was found between cortical and mixed cortical--nuclear cataract and loss of GST activity. No association was found between pure nuclear cataract and loss of epithelial GST activity. SN - 0271-3683 UR - https://www.unboundmedicine.com/medline/citation/8344067/Distribution_and_activity_of_glutathione_S_transferase_in_normal_human_lenses_and_in_cataractous_human_epithelia_ L2 - https://www.tandfonline.com/doi/full/10.3109/02713689309024625 DB - PRIME DP - Unbound Medicine ER -