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Inhibition of melatonin secretion by ethanol in man.

Abstract

To determine whether ethanol inhibits nocturnal melatonin (MT) secretion, three experiments (A, B, and C) were performed in seven normal subjects. In A, ethanol at a dose of 0.34 g/kg was administered orally at 6:00, 8:00, and 10:00 PM. Each dose was increased to 0.52 g/kg in B. In C, water was substituted for ethanol. Blood samples for determination of serum MT levels were drawn every second hour between 6:00 PM and 8:00 AM. Urinary excretion of MT during the night was also determined. In A, serum ethanol reached a maximal level of 13 +/- 1 mmol/L at 12 midnight. In B, the corresponding maximum was 25 +/- 1 mmol/L. The higher alcohol dose inhibited nocturnal MT secretion by 20% +/- 5% (P < .01), whereas the lower dose lacked such effect. Urinary excretion of MT was left unaffected by alcohol at both doses. Five additional normal subjects were given alcohol as described above at a dose of 0.52 g/kg (experiment D). This induced mild nocturnal hypoglycemia as evidenced by a glucose decremental area (5.9 +/- 1.8 mmol/L.h) that differed significantly from zero (P < .05). To determine whether a reduced glucose delivery to pinealocytes might contribute to the decreased MT secretion in alcohol-intoxicated subjects, two experiments (E and F) were performed in eight healthy individuals. In E, ethanol was given orally as in B; three small oral doses of glucose were also given at 8:00 PM, 10:00 PM, and 12 midnight. In F, water was substituted for ethanol and glucose.(

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  • Authors+Show Affiliations

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    Department of Internal Medicine, Södersjukhuset, Stockholm, Sweden.

    , , ,

    Source

    Metabolism: clinical and experimental 42:8 1993 Aug pg 1047-51

    MeSH

    Administration, Oral
    Adult
    Dose-Response Relationship, Drug
    Drug Synergism
    Ethanol
    Female
    Glucose
    Humans
    Hypoglycemia
    Male
    Melatonin
    Radioimmunoassay

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8345809

    Citation

    Röjdmark, S, et al. "Inhibition of Melatonin Secretion By Ethanol in Man." Metabolism: Clinical and Experimental, vol. 42, no. 8, 1993, pp. 1047-51.
    Röjdmark S, Wikner J, Adner N, et al. Inhibition of melatonin secretion by ethanol in man. Metab Clin Exp. 1993;42(8):1047-51.
    Röjdmark, S., Wikner, J., Adner, N., Andersson, D. E., & Wetterberg, L. (1993). Inhibition of melatonin secretion by ethanol in man. Metabolism: Clinical and Experimental, 42(8), pp. 1047-51.
    Röjdmark S, et al. Inhibition of Melatonin Secretion By Ethanol in Man. Metab Clin Exp. 1993;42(8):1047-51. PubMed PMID: 8345809.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Inhibition of melatonin secretion by ethanol in man. AU - Röjdmark,S, AU - Wikner,J, AU - Adner,N, AU - Andersson,D E, AU - Wetterberg,L, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 1047 EP - 51 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 42 IS - 8 N2 - To determine whether ethanol inhibits nocturnal melatonin (MT) secretion, three experiments (A, B, and C) were performed in seven normal subjects. In A, ethanol at a dose of 0.34 g/kg was administered orally at 6:00, 8:00, and 10:00 PM. Each dose was increased to 0.52 g/kg in B. In C, water was substituted for ethanol. Blood samples for determination of serum MT levels were drawn every second hour between 6:00 PM and 8:00 AM. Urinary excretion of MT during the night was also determined. In A, serum ethanol reached a maximal level of 13 +/- 1 mmol/L at 12 midnight. In B, the corresponding maximum was 25 +/- 1 mmol/L. The higher alcohol dose inhibited nocturnal MT secretion by 20% +/- 5% (P < .01), whereas the lower dose lacked such effect. Urinary excretion of MT was left unaffected by alcohol at both doses. Five additional normal subjects were given alcohol as described above at a dose of 0.52 g/kg (experiment D). This induced mild nocturnal hypoglycemia as evidenced by a glucose decremental area (5.9 +/- 1.8 mmol/L.h) that differed significantly from zero (P < .05). To determine whether a reduced glucose delivery to pinealocytes might contribute to the decreased MT secretion in alcohol-intoxicated subjects, two experiments (E and F) were performed in eight healthy individuals. In E, ethanol was given orally as in B; three small oral doses of glucose were also given at 8:00 PM, 10:00 PM, and 12 midnight. In F, water was substituted for ethanol and glucose.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/8345809/Inhibition_of_melatonin_secretion_by_ethanol_in_man_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(93)90021-F DB - PRIME DP - Unbound Medicine ER -