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Inhibition of melatonin secretion by ethanol in man.
Metabolism. 1993 Aug; 42(8):1047-51.M

Abstract

To determine whether ethanol inhibits nocturnal melatonin (MT) secretion, three experiments (A, B, and C) were performed in seven normal subjects. In A, ethanol at a dose of 0.34 g/kg was administered orally at 6:00, 8:00, and 10:00 PM. Each dose was increased to 0.52 g/kg in B. In C, water was substituted for ethanol. Blood samples for determination of serum MT levels were drawn every second hour between 6:00 PM and 8:00 AM. Urinary excretion of MT during the night was also determined. In A, serum ethanol reached a maximal level of 13 +/- 1 mmol/L at 12 midnight. In B, the corresponding maximum was 25 +/- 1 mmol/L. The higher alcohol dose inhibited nocturnal MT secretion by 20% +/- 5% (P < .01), whereas the lower dose lacked such effect. Urinary excretion of MT was left unaffected by alcohol at both doses. Five additional normal subjects were given alcohol as described above at a dose of 0.52 g/kg (experiment D). This induced mild nocturnal hypoglycemia as evidenced by a glucose decremental area (5.9 +/- 1.8 mmol/L.h) that differed significantly from zero (P < .05). To determine whether a reduced glucose delivery to pinealocytes might contribute to the decreased MT secretion in alcohol-intoxicated subjects, two experiments (E and F) were performed in eight healthy individuals. In E, ethanol was given orally as in B; three small oral doses of glucose were also given at 8:00 PM, 10:00 PM, and 12 midnight. In F, water was substituted for ethanol and glucose.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Internal Medicine, Södersjukhuset, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8345809

Citation

Röjdmark, S, et al. "Inhibition of Melatonin Secretion By Ethanol in Man." Metabolism: Clinical and Experimental, vol. 42, no. 8, 1993, pp. 1047-51.
Röjdmark S, Wikner J, Adner N, et al. Inhibition of melatonin secretion by ethanol in man. Metab Clin Exp. 1993;42(8):1047-51.
Röjdmark, S., Wikner, J., Adner, N., Andersson, D. E., & Wetterberg, L. (1993). Inhibition of melatonin secretion by ethanol in man. Metabolism: Clinical and Experimental, 42(8), 1047-51.
Röjdmark S, et al. Inhibition of Melatonin Secretion By Ethanol in Man. Metab Clin Exp. 1993;42(8):1047-51. PubMed PMID: 8345809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of melatonin secretion by ethanol in man. AU - Röjdmark,S, AU - Wikner,J, AU - Adner,N, AU - Andersson,D E, AU - Wetterberg,L, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 1047 EP - 51 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 42 IS - 8 N2 - To determine whether ethanol inhibits nocturnal melatonin (MT) secretion, three experiments (A, B, and C) were performed in seven normal subjects. In A, ethanol at a dose of 0.34 g/kg was administered orally at 6:00, 8:00, and 10:00 PM. Each dose was increased to 0.52 g/kg in B. In C, water was substituted for ethanol. Blood samples for determination of serum MT levels were drawn every second hour between 6:00 PM and 8:00 AM. Urinary excretion of MT during the night was also determined. In A, serum ethanol reached a maximal level of 13 +/- 1 mmol/L at 12 midnight. In B, the corresponding maximum was 25 +/- 1 mmol/L. The higher alcohol dose inhibited nocturnal MT secretion by 20% +/- 5% (P < .01), whereas the lower dose lacked such effect. Urinary excretion of MT was left unaffected by alcohol at both doses. Five additional normal subjects were given alcohol as described above at a dose of 0.52 g/kg (experiment D). This induced mild nocturnal hypoglycemia as evidenced by a glucose decremental area (5.9 +/- 1.8 mmol/L.h) that differed significantly from zero (P < .05). To determine whether a reduced glucose delivery to pinealocytes might contribute to the decreased MT secretion in alcohol-intoxicated subjects, two experiments (E and F) were performed in eight healthy individuals. In E, ethanol was given orally as in B; three small oral doses of glucose were also given at 8:00 PM, 10:00 PM, and 12 midnight. In F, water was substituted for ethanol and glucose.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/8345809/Inhibition_of_melatonin_secretion_by_ethanol_in_man_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(93)90021-F DB - PRIME DP - Unbound Medicine ER -